Infection and immunity
Mae'r cynnwys hwn ar gael yn Saesneg yn unig.
We conduct high quality basic and translational research that is internationally recognised, widely referenced and globally exploited for the benefit of human health.
Our research is grouped into four themes, each led by an integrated team of non-clinical and clinical academic staff who deliver fundamental and applied research of translational relevance. Many of our clinical research leads have joint NHS appointments combined with protected research time.
We deliver a large component of teaching within undergraduate medical and pharmacology teaching programmes in the form of lectures, practicals, tutorials and demonstrations, with an emphasis on small group teaching within years 2 - 4. We are also involved in postgraduate teaching, teaching administration, assessment and curriculum development.
The majority of our research is conducted through the Systems Immunity Research Institute.
Aims
- To understand the underlying biology of infectious diseases.
- To understand immune system function and dysfunction during health and disease.
- To exploit this understanding to develop novel therapeutic and diagnostic approaches.
- To disseminate this knowledge to the public, patients, professionals and students.
Themes
Haint
Mae gennym bortffolio eang o ddiddordebau ymchwil gyda chryfderau penodol mewn firoleg, imiwnoleg firaol, ymwrthedd gwrthficrobaidd a diagnosis o haint ffwngaidd.
Mae cysylltiadau agos â'r GIG a phartneriaid diwydiannol yn hwyluso ymchwil drosiadol ac yn caniatáu gwerthusiad clinigol o fethodolegau a diagnosteg newydd.
Arweinydd thema
Maes o ddiddordeb
Firoleg
Prif aelodau staff
| Enw | Maes o ddiddordeb |
|---|---|
| Yr Athro Gavin Wilkinson | |
| Dr Brad (Owen) Spiller | |
| Dr Mark Toleman | Ymwrthedd gwrthfiotig mewn bacteria |
| Yr Athro Sailesh Kotecha | Pediatreg clinigol a haint mewn babanod |
| Yr Athro Edward Wang | Imiwnoleg Cellog |
| Dr Kristin Ladell | Mecanweithiau imiwnedd addasol |
| Yr Athro David Price | Mecanweithiau imiwnedd addasol |
| Dr Ceri Fielding | Evasion Imiwnedd firaol |
| Yr Athro Ian Humphreys | In vivo modelau llid firaol |
Grwpiau Ymchwil
Inflammation
Inflammation represents the coordinated immune response to infection, trauma and injury.
When appropriately controlled, inflammation ensures competent host defence and prevents excessive damage of the affected tissue or organ structure.
In chronic inflammatory diseases, this process is disrupted and instead of offering protection, drives disease progression.
Theme lead
Area of interest
Cytokine immunology in chronic disease progression.
Principal members of staff
| Name | Area of interest |
|---|---|
| Professor Ernest Choy | Clinical rheumatology and biologic drug therapies |
| Dr Charlotte Rawlings | Clinical rheumatology |
| Professor Andrew Finlay | Infection |
| Professor Paul Martin | Cancer and wound healing |
| Dr John Ingram | Clinical dermatology |
| Professor Valerie O'Donnell | Lipidomics |
| Professor Peter Collins | Clinical haematology and clotting |
| Professor Paul Morgan | Complement biology, neuroimmunology |
| Professor Kathy Triantafilou | |
| Dr Martha Triantafilou | Innate sensing mechanisms |
| Dr Timothy Hughes | Complement biology, cardiovascular disease |
| Professor Donald Fraser | Clinical nephrology and fibrosis |
| Dr Timothy Bowen | MicroRNA |
| Dr Mario Labeta | Innate sensing mechanisms |
| Dr Anne-Catherine Raby | Innate sensing mechanisms |
| Professor Aled Phillips | Clinical nephrology and renal scarring |
| Dr Robert Steadman | Clinical nephrology and renal scarring |
| Dr Soma Meran | Clinical nephrology and fibrosis |
| Professor Philip Taylor | Monocytic cell biology |
| Professor Anwen Williams | Experimental rheumatology |
| Dr Gareth Jones | Cytokine immunology in chronic disease progression |
| Dr Selinda Orr | Innate sensing mechanisms |
Research Groups
Immunology
Our immunology research spans the gamut from basic molecular studies through to clinical trials and new patient treatments.
We are particularly strong in the areas of conventional and unconventional T-cell immunity, cancer immunotherapy, autoimmune disease, homing and trafficking of immune cells and the structure biology of antigen receptors and the ligands they recognise.
Theme lead
Yr Athro Susan Wong
Professor of Experimental Diabetes & Metabolism
- wongfs@caerdydd.ac.uk
- +44 (0)29 2068 7000
Area of interest
T-cell ligands and the receptors that recognise them during infection, autoimmune disease, organ transplant and cancer immunotherapy.
Principal members of staff
| Name | Area of interest |
|---|---|
| Professor Jamie Rossjohn | Structure and biophysics of innate and adaptive immune recognition |
| Dr Pierre Rizkallah | Protein structure biology |
| Professor Colin Dayan | Autoimmune disease |
| Professor Susan Wong | Type 1 diabetes |
| Professor Bernhard Moser | Immune cell migration |
| Professor Andrew Godkin | MHC class II and cancer immunotherapy |
| Professor Awen Gallimore | Immune tolerance and cancer immunotherapy |
| Professor Matthias Eberl | Unconventional T-cells |
| Professor Ann Ager | Lymphocyte homing |
