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Bowen, Tim

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Timothy Bowen

Section of Nephrology, Institute of Molecular & Experimental Medicine,

Cardiff University School of Medicine

Senior Lecturer in Matrix and Molecular Biology

029 2074 8389

029 2074 8470

bowent@cf.ac.uk

 

Relevant Key Words:

gene expression, hyaluronan synthases, noncoding RNAs, urinary microRNAs, renal fibrosis, chronic kidney disease

 

Research Expertise relevant to tissue engineering & repair:

Core Nephrology research themes include determination of the pathophysiological mechanisms underlying renal fibrosis and the progression of chronic kidney disease.  Fibrosis is associated with increased cortical synthesis of hyaluronan, a glycosaminoglycan of the extracellular matrix.

Our work focuses on the regulation of gene expression in renal disease and current areas of interest include:

· Transcriptional regulation of the genes encoding the human hyaluronan synthases, as well as other fibrosis-associated genes including noncoding RNAs HAS2-AS1 and microRNA-192

· Post-transcriptional regulation of the human hyaluronan synthase 2 (HAS2) gene by its natural antisense RNA, HAS2-AS1

· Post-transcriptional regulation of fibrosis-associated genes by microRNAs

· Analysis of urinary microRNAs as candidate biomarkers for chronic kidney disease

· Interaction of gene expression and cell phenotype, and the effects of this interaction on the progression of renal disease

 

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