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Smith, Paul

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Professor Paul J Smith

Institute of Cancer & Genetics, School of Medicine

Professor of Cancer Biology

029 2068 7335

029 2068 7343

smithpj2@cf.ac.uk

 

Relevant Key Words:

Cell cycle; anticancer drugs; imaging; flow cytometry; fluorescence; dielectrophoresis; lasers

 

Research Expertise relevant to tissue engineering & repair:

My laboratory has been recognised for its state-of-the-art flow cytometric and imaging studies as applied to problems in cancer biology.  A focus has been DNA damage responses in human tumour cells and linkage with cell cycle control.   Current work is centred on the cell cycle as a target for anticancer agents and the development of technologies to support drug discovery.  We have links with drug development groups with a long term aim of progressing agents through to trials.  An important aspect of this is the development of mathematical modelling for cellular heterogeneity and drug responses with the University of Warwick.

Our technology development studies have focused on optical biochips (http://gow.epsrc.ac.uk/ViewGrant.aspx?GrantRef=GR/S23483/01) incorporating microelectrode structures to allow the electrokinetic actuation of cells in AC electric fields - for example by dielectrophoresis (DEP). We have exploited basic dielectrophoresis (DEP) and fluidic phenomena on our biochip platforms to provide solutions for cell processing and analysis supported by genetic algorithms to resolve DEP data. Such probless DEP profiling of cells provides opportunities for the evaluation and sorting of cells used in tissue engineering applications.

 

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