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Davies, Lindsay

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Dr Lindsay Catrina Davies

Wound Biology Group, Tissue Engineering and Reparative Dentistry

School of Dentistry, Cardiff University, Heath Park, Cardiff CF14 4XY

Lecturer in Stem Cell Immunology

029 2074 4252

029 2074 2546

davieslc1@cardiff.ac.uk

 

Relevant Key Words:

Tissue engineering, progenitor/stem cells, oral mucosa, neural crest, immunomodulation, wound healing, stem cell and bacterial interactions, Graft Versus Host Disease

 

Research Expertise relevant to tissue engineering & repair:

My postdoctoral research has focussed on my developing interest in stem/progenitor cell (PC) biology and the identification of a novel PC population within the oral mucosa lamina propria. This work has stemmed from my interest in the preferential healing seen within the oral mucosa compared to the skin. Within the oral mucosa rapid healing is seen within no/minimal scar formation upon wounding. My recent work has focussed on characterising this newly discovered PC population which may contribute to this preferential healing response. In particular this research has focussed on determining the neural-crest origin of this cell population, and successfully differentiating the cells down mesenchymal, neuronal and glial lineages with a view to future therapeutic applications (Davies et al., 2010). Prizes (Senior Colgate Prize for Basic Research, British Society of Dental Research 2007 and International Association of Dental Research Travel Award, 2008) which I have been awarded for this research (along with further funding from the CITER, 2008) provided support for me to establish a collaborative link with and carry out work at the Karolinska Institute in Sweden, investigating the immunological properties of this cell population with Professor Katarina Le Blanc, a world renowned stem cell immunologist. This has led to a continuing portfolio of research focussing on the mechanisms by which oral mucosal PCs are able to evade the immune response and potentially interact with pathogenic bacteria in addition to their potential for allogeneic transplantation and the treatment of immune related disorders, such as Graft Versus Host Disease (Davies et al., 2012).

Publications

1. Oral Mucosal Progenitor Cells are Potently Immunosuppressive in a Dose Independent Manner. LC Davies, Lönnies H, Locke M, Sundberg B, Rosendahl K, Götherström C, Le Blanc K, Stephens P. Stem Cells and Development, 2012; Jun 10;21(9):1478-87
2. ‘Young’ Oral Fibroblasts are Geno/phenotypically Distinct. S Enoch, Wall I, Peake M, Davies L, Farrier J, Giles P, Baird D, Kipling D, Price P, Moseley R, Thomas D, Stephens P. Journal of Dental Research, 2010 Dec; 89(12) 1407-13
3. A Multipotent Neural Crest Derived Progenitor Cell Population is Resident within the Oral Mucosa Lamina Propria. LC Davies, Locke M, Webb RJ, Roberts JT, Langley M, Thomas DW, Archer C, Stephens P. Stem Cells and Development, 2010 June; 19(6):819-30
4. Increased Oral Fibroblast Lifespan is Telomerase-Independent. S Enoch, Wall I, Peake M, Davies L, Farrier J, Giles P, Baird D, Kipling D, Price P, Moseley R, Thomas D, Stephens P. Journal of Dental Research, 2009 Oct; 88(10):916-21.
5. Chondroitin Sulphate Impedes the Migration of a Sub-Population of Articular Cartilage Chondrocytes. LC Davies, Blain EJ, Caterson B, Duance VC. Osteoarthritis and Cartilage, 2008 Aug;16(8):855-64.
6. The Potential of IGF-1 for Promoting Adult Articular Cartilage Repair: an in Vitro Study. LC Davies, Blain EJ, Gilbert SJ, Caterson B, Duance VC. Tissue Engineering Part A. 2008 Jul;14(7):1251-61.

Patents:
New British Patent Application No 0810841.7 - Oral Mucosal Progenitor Cells
New British Patent Application No 0811865.5 - Oral Mucosal Progenitor Cells
New British Patent Application No 0820012.3 – Oral Mucosal Progenitor Cells
International Patent Application No PCT/GB2009/001443 – Oral Mucosa
Australian Patent Application No AU2009259053
European Patent Application No E09761964.7
Chinese Patent Application No CN200980122121.0
Japanese Patent Application No JP501125275
United States of America Patent Application No US12/997,363

 

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