Connective Tissue Biology Laboratory, School of Biosciences, Cardiff University
Professor of Biochemistry
029 2087 4595
029 2087 6691
Relevant Key Words:
Cartilage metabolism, Connective Tissue Proteoglycans, Arthritis
Research Expertise relevant to tissue engineering & repair:
Professor Bruce Caterson is currently a Professor of Biochemistry within the School of Biosciences, Cardiff University. Over the past 30 years his interests have been in studies investigating the structure, function and metabolism of connective tissue proteoglycans in health and disease with a particular emphasis on cartilage proteoglycan metabolism in the pathogenesis of arthritis. At present our main interests focus on investigating the molecular mechanisms involved in the catabolism of cartilage matrix macromolecules that lead to cartilage degradation in arthritis. Our laboratories main research technology contributions have been in the development and use of monoclonal antibody technologies to study cartilage matrix metabolism. These monoclonal antibody reagents are also being used to investigate the extracellular matrix composition, organisation and integration after autologous chondrocyte transplantation in cartilage repair and tissue engineering procedures. Similarly, these reagents are being used, in parallel with biophysical analyses, to study corneal matrix structural organisation during development and with repair after injury (Profs. Keith Meek & and Dr Andrew Quantock, Optometry). In recent years he has collaborated with Professor John L. Harwood (Biosciences) on studies investigating the molecular mechanisms involved in explaining how n-3 (omega-3) fatty acid supplementation influences cartilage metabolism by abrogating the activity of proteolytic enzymes that destroy cartilage and inflammatory factors that propagate inflammation in arthritic diseases. He has similar collaborations with Professor Chris McGuigan (School of Pharmacy) investigating mechanisms underlying the chondroprotective effects of glucosamine derivatives in the pathogenesis of arthritic diseases. Related studies are also ongoing through an EPSRC Platform Grant with Professor Ruth Duncan (School of Pharmacy) & Dr Peter Griffiths (Chemistry) investigating the use of biodegradable polymers as nanotechnology methods for delivering nutraceuticals and drugs in the treatment of degenerative joint diseases.
If you have reagents that may be of interest to the CITER Membership, e.g. cell lines, microbiological cultures. Please give a representative list below:
Our lab has produced and characterised a large number of monoclonal antibody reagents that specifically detect epitopes on connective tissue proteoglycans; i.e. protein and carbohydrate/glycosaminoglycan epitopes and neoepitopes.