Relevant Key Words:

Bone, osteoblasts, osteoclasts, osteocytes, adipocytes, osteoporosis, osteoarthritis

Research Expertise relevant to tissue engineering & repair:

My research interests are focussed on the pathophysiology of bone diseases eg osteoporosis, osteoarthritis. More specifically current research projects can be summarised as:-
- development of 3D models to study bone cells in vitro
- responses of osteocytes to mechanical loading
- the influences of chemotherapy on bone cell number and function in relation to childhood leukaemia
- the role of the osteocyte in the development of osteonecrosis
- effects of growth hormone deficiency and growth hormone treatment on bone
- the control of bone marrow mesenchymal stem cell differentiation into osteoblasts and adipocytes
- the role of purinergic receptors (especially adenosine receptors) in bone cells
- targeting ion channels as potential new therapies for bone disease
- co-cultures (especially 3D) of different bone cell types

School profile page

If you have reagents that may be of interest to the CITER Membership, e.g. cell lines, microbiological cultures. Please give a representative list below:

Numerous osteoblast, osteoclast and osteocyte cell lines stored in liquid nitrogen. I also often use primary animal or human bone cells.