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Workshop programme 2014 

Cell Signalling

#cellsignalling

On - Wednesday 30th April, 13:30-16:45pm 

Venue: Sir Martin Evans Building, Museum Avenue, Cardiff University:  

Our speakers include:

Dr Gwendolen Reilly, Department of Materials Science and Engineering, University of Sheffield who will be speaking on "Mechanical signalling by bone cell membrane sensors";

Abstract: It has been well demonstrated that bone cells respond to mechanical forces in the body and in vitro. These responses can be harnessed to create mechanically stable tissues for regenerative medicine applications. Tissue engineering provides 3D matrices in which mechanobiological responses of cells can be measured in an environment more similar to in vivo. In our laboratory we use a range of bioreactors to mechanically stimulate bone cells and osteogenic precursors in 2D and 3D. These cells respond to mechanical stimulation with increases in matrix production, recently we have shown that even dermal fibroblasts from skin can be induced to osteogenesis by mechanical loading. Using these models we examine the mechanisms by which cells orientate their matrix based on intrinsic and external mechanical forces.  We also examine mechanotransduction mechanisms; for example we have shown that cell membrane structures such as the glycocalyx a proteoglycan rich membrane coat and the primary cilia a single non-motile cilia that projects from each cell have roles in mechanosensing in vitro.

Dr Mark Bass, School of Biochemistry, University of Bristol  who will be presenting his research on "Ultrasonic Activation of Fibroblasts as a Wound Healing Therapy";

Professor Maurice Hallet, School of Medicine, Cardiff University "Stopping inflammatory cell extravasation: signalling the way to therapy" 

Abstract: We are interested in understanding the intracellular signalling which triggers inflammatory cells to change from their passive spherical shape as they are pushed around the circulation into polarised and adherent cells which then leave the blood stream. This is the key stage for regulating trafficking into the inflamed site and we think that in neutrophils, at least, we understand it. By a lucky chance, we also found that this signalling pathway is amenable to inhibition by some novel small molecular weight compounds, which we hope can be developed into to useful anti-inflammatory drugs. 

Professor Simon Jones, School of Medicine, Cardiff University "Dissecting the role of STAT1 and STAT3 in determining tissue chronicity and disease progression".

 

Further details to follow.

To register for this afternoon workshop then please contact CITER Administrator Jane Graves, GravesJA@cf.ac.uk .

 

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