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New Research Associates
We are delighted to welcome Dr Enas Behiry and Dr Andrew Wood to the group! Enas returns to lend her experience in dihydrofolate reductase to our enzyme mechanisms project while Andy will add LOV domain expertise to our work on genetically encoded photoswitches.
Dynamical Motions in Catalysis
The Journal of the American Chemical Society has spotlit our recent communication. They conclude that our study suggests that proteins motions are not universally coupled to reaction kinetics but offers clues into the types of evolutionary trade-offs that may occur in enzymes to gain thermal stability.
Read more here.
The press release circulated by the Cardiff University public relations team has inspired someone to create a wikipedia page.
It's a Knock In!
The School of Chemistry web pages have higlighted our new paper on enzyme mechanisms. We show that although a particular dihydrofolate mutant has previously been termed a 'dynamic knock-out' enzyme with reduced motions on a millisecond timescale, it is better considered to be a 'dynamic knock-in' at timescales relevant to chemical reactions, as increased femtosecond time scale motions are responsible for the loss of activity.
See the chemistry website news pages for more details.
Peptide Nanoswitches Featured
Our peptide nanoswitch project has been highlighted on the Cardiff University website news centre.
Enzyme Mechanistic Study Highlighted
The Cardiff University website has publicised our new paper in the Proceedings of the National Academy of Science (USA). The paper examines the effect of making 'heavy enzymes', synthesised to contain heavy isotopes of carbon, nitrogen and hydrogen. The effects of this heavier constitution on the rate of catalysis at dfferent temperatures are explored and matched to modelling results provided by coleagues from Bristol University.
Front Cover for Peptide Nanoswitches
Our illustration was chosen for the front cover of Molecular Biosystems! The article (here) describes how photo-control of the conformation of peptides can be used to activate the first stages of apoptosis in cancer cells. The cover illustration shows molecular model cartoons depicting lit and unlit peptides whose shadows show the effect on the conformation of the peptide backbone.
Front Cover for Semiochemistry of Aphids
A review article written by Dr John Pickett, Professor Allemann and Dr Michael Birkett on the semiochemistry of small sap feeding insects in Natural Product Reports has been chosen for a front cover illustration.
We are delighted to welcome Antonio Angelastro and
Marianna Loizzi to the group! Antonio will join our enzyme mechanisms research and Marianna will join our terpene cyclases project.
Professor Allemann Elected to Learned Society
Professor Rudolf Allemann has been elected as a fellow of the Learned Society of Wales. The Society, which was formed in 2010 to represent Welsh learning, elects its fellows against the criterion of a demonstrable record of excellence and achievement in an academic discipline.