It's a Knock In!
The School of Chemistry web pages have higlighted our new paper on enzyme mechanisms. We show that although a particular dihydrofolate mutant has previously been termed a 'dynamic knock-out' enzyme with reduced motions on a millisecond timescale, it is better considered to be a 'dynamic knock-in' at timescales relevant to chemical reactions, as increased femtosecond time scale motions are responsible for the loss of activity.
See the chemistry website news pages for more details.
The press release circulated by the Cardiff University public relations team has inspired someone to create a wikipedia page.
Peptide Nanoswitches Featured
Our peptide nanoswitch project has been highlighted on the Cardiff University website news centre.
Enzyme Mechanistic Study Highlighted
The Cardiff University website has publicised our new paper in the Proceedings of the National Academy of Science (USA). The paper examines the effect of making 'heavy enzymes', synthesised to contain heavy isotopes of carbon, nitrogen and hydrogen. The effects of this heavier constitution on the rate of catalysis at dfferent temperatures are explored and matched to modelling results provided by coleagues from Bristol University.
Front Cover for Peptide Nanoswitches
Our illustration was chosen for the front cover of Molecular Biosystems! The article (here) describes how photo-control of the conformation of peptides can be used to activate the first stages of apoptosis in cancer cells. The cover illustration shows modecular model cartoons depicting lit and unlit peptides whose shadows show the effect on the confomation of the peptide backbone.
Front Cover for Semiochemistry of Aphids
A review article written by Dr John Pickett, Professor Allemann and Dr Michael Birkett on the semiochemistry of small sap feeding insects in Natural Product Reports has been chosen for a front cover illustration.
We are delighted to welcome Antonio Angelastro and Marianna Loizzi to the group! Antonio will join our enzyme mechanisms research and Marianna will join our terpene cyclases project.
Professor Allemann Elected to Learned Society
Professor Rudolf Allemann has been elected as a fellow of the Learned Society of Wales. The Society, which was formed in 2010 to represent Welsh learning, elects its fellows against the criterion of a demonstrable record of excellence and achievement in an academic discipline.
Review Article Makes Most-Read List
Dr David Miller and Professor Rudolf Allemann's review "Sesquiterpene synthases: Passive catalysts or active players?" continues to provoke interest. The RSC Publishing Natural Products blog has revealed that it is one of their ten most accessed articles of the year!