Imaging Work Featured in Chemistry World
15 February 2011
Work by Mike Coogan and Flora Thorp-Greenwood from the School of Chemistry, along with collaborators from Bioscience, has been featured in the research news section of the RSC magazine Chemistry World. http://www.rsc.org/chemistryworld/News/2011/February/11021105.asp
The work which was published in Chem. Comm. (http://xlink.rsc.org/?doi=C1CC10141B) describes a novel strategy for transporting metal ions into cells, which the authors have called the ‘Sleeping Trojan Horse’. Trojan horse strategies for delivering drugs and other materials into cells are common, but usually require conjugation of the delivery vector to the cargo and purification. The ‘Sleeping Trojan Horse’ is a luminescent molecular vessel which in its ‘sleeping’ state before metal–loading is incapable of entering cells, but is awoken to a permeant state upon loading. As this happens rapidly, and the vessel is capable of carrying metals which have positron-emitting isotopes it has potential for bimodal fluorescence and PET imaging. While this is a prototype, it is interesting that fluorescence imaging shows that not only does the metal-bearing form enter cells but it also localises in the nucleolus, giving additional potential for radiotherapy as well as imaging.