Prof Keith Smith - BSc MSc PhD CChem FRSC FLSW
Telephone:+44 (0)29 208 70600
Fax:+44 (0)29 208 70600
Research Group: Organic Synthesis
Professor Smith’s research interests are primarily in the development of novel synthetic methods, especially ones that are “green”, and syntheses of compounds with interesting, especially photoactive, properties.
The main thrust of our research work has always been to develop novel methods that have general synthetic utility. Our early work concentrated on the applications of organoboron reagents, which at the time were relatively little known, but are now extremely widely used. This led us into the applications of other main group elements and especially lithiation reactions, which we have used to devise novel heterocyclic ring syntheses and to introduce selectivity into aromatic and heterocyclic substitution reactions. In recent years we have developed new approaches “green” processes for synthesis of commercially important
products, especially in the area of selective electrophilic aromatic substitution reactions, which are of major industrial importance but are traditionally often very unselective and messy reactions. One of the major tools to provide the selectivity is the use of microporous solid catalysts such as zeolites. We are also interested in supported catalysts and reagents, where the supports can be inorganic or an organic polymer. We are also interested in synthesising target compounds that have interesting properties. Many such compounds have a heterocyclic ring at the centre of their structure and we have specific interests in photoactive materials.
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