Dr James Redman - MA (Oxon) PhD
Links
Research Group: Biological and Organic Chemistry
Personal Web Site: James Redman
Research Interests
Dr Redman’s research interests are in the areas of amino acid, protein and peptide chemistry, nucleic acids and mass spectrometry.
This work involves the synthesis of amino acids with heterocyclic side chains designed as building blocks for nucleic acid-binding peptides. We are preparing amino acids with mono- and bicyclic guanidine side chains as constrained analogues of arginine that are predicted to form hydrogen bonded interactions with nucleobases. Peptides can also be constrained by backbone cyclisation and we are investigating the use of computer aided interpretation of collision induced dissociation mass spectra of cyclic peptides as a tool for characterisation of this class of compound. A further project involves using phage display techniques to select allosteric DNA binding proteins, with the goal of creating artificial transcription factors that can be switched using a small molecule drug.
For more information, click on the 'Research' tab above.
Teaching
CH0003 Chemistry of Organic Compounds
CH3216 Chemical Biology II: Introduction to Enzyme and Nucleic Acid Chemistry
CH2317 Chemical Biology III: Biosynthetic Approach to Natural Products
CH2404 Reterosynthetic Analysis and Biosynthesis
CHT224 Medicinal Chemistry