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Dr James Redman  -  MA (Oxon) PhD


Dr James Redman
Position:Lecturer in Chemical Biology

Telephone:+44 (0)29 208 76273
Fax:+44 (0)29 208 74030

Links

Research Group: Biological and Organic Chemistry

Personal Web Site: James Redman

Research Interests

Dr Redman’s research interests are in the areas of amino acid, protein and peptide chemistry, nucleic acids and mass spectrometry.
This work involves the synthesis of amino acids with heterocyclic side chains designed as building blocks for nucleic acid-binding peptides. We are preparing amino acids with mono- and bicyclic guanidine side chains as constrained analogues of arginine that are predicted to form hydrogen bonded interactions with nucleobases. Peptides can also be constrained by backbone cyclisation and we are investigating the use of computer aided interpretation of collision induced dissociation mass spectra of cyclic peptides as a tool for characterisation of this class of compound. A further project involves using phage display techniques to select allosteric DNA binding proteins, with the goal of creating artificial transcription factors that can be switched using a small molecule drug.

For more information, click on the 'Research' tab above.

Teaching

CH0003 Chemistry of Organic Compounds

CH3216 Chemical Biology II: Introduction to Enzyme and Nucleic Acid Chemistry

CH3217 Biomolecular Chemistry

CH2317 Chemical Biology III: Biosynthetic Approach to Natural Products

CH3405 Organic Chemistry 2

CHT224 Medicinal Chemistry