Dr James Redman - MA (Oxon) PhD
Telephone:+44 (0)29 208 76273
Fax:+44 (0)29 208 74030
Research Group: Biological and Organic Chemistry
Personal Web Site: James Redman
Dr Redman’s research interests are in the areas of amino acid, protein and peptide chemistry, nucleic acids and mass spectrometry.
This work involves the synthesis of amino acids with heterocyclic side chains designed as building blocks for nucleic acid-binding peptides. We are preparing amino acids with mono- and bicyclic guanidine side chains as constrained analogues of arginine that are predicted to form hydrogen bonded interactions with nucleobases. Peptides can also be constrained by backbone cyclisation and we are investigating the use of computer aided interpretation of collision induced dissociation mass spectra of cyclic peptides as a tool for characterisation of this class of compound. A further project involves using phage display techniques to select allosteric DNA binding proteins, with the goal of creating artificial transcription factors that can be switched using a small molecule drug.
For more information, click on the 'Research' tab above.
CH0003 Chemistry of Organic Compounds
CHT224 Medicinal Chemistry