Mechanisms of glioblastoma recurrence

Glioblastoma is the most common and lethal of the brain cancers, and the re-appearance, or recurrence, of these cancers after treatment is a particular problem contributing to patient demise.

Dr Siebzehnrubl's research is directed at identifying molecular mechanisms that allow cancer cells to regrow into new tumours after therapy. He is particularly interested in how a protein called ZEB1 is enabling cancer stem cells to escape therapy and initiate recurrence.