Maternal regulation of reprogramming and stem cells

Cancer is a problem of developmental biology. There are many molecular links between embryogenesis and oncogenesis.

Some cancerous cells use a transcriptional programme that is active in embryonic stem cells. Uncovering the mechanistic similarity between early embryonic development and cancerous cell initiation may therefore help develop a new strategy to treat cancers. 

Dr Liming Gui's previous studies focused upon tumorigenesis and oocyte-based developmental biology using cell culture and/or mice as model systems. Her research interest is mechanistic studies on how epigenetic regulation of transcription program controls developmental differentiation. The proposed project is to explore the possibility that maternal regulation of transcription reprogramming could be exploited to induce cancerous cell differentiation.