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Learn about the work our research groups are doing and the people involved.


Intestinal Cancer Research

The Intestinal Cancer Research Group models colorectal cancer in the mouse and assesses pathway synergies and antagonisms in-vivo and validating therapeutic targets.

breast cancer cells

Tumour Heterogeneity

The Tumour Heterogeneity group is trying to understand why tumours which originate in a single tissue can have very different appearances in biology and behaviour.


Targeting Metastasis

The Targeting Metastasis group focuses on identifying novel therapeutic strategies to eliminate or modify the cancer cells responsible for the spread of tumours around the body.

microscope with slides

Leukaemic Stem Cells

The Leukaemic Stem Cells group focusses on understanding and therapeutically targeting leukaemic stem cells in acute myeloid leukaemia.

Image of a fly midgut

Stem Cell Fate Dynamics

The Stem Cell Fate Dynamics group focuses on understanding the molecular mechanisms whereby tissue stem cells balance differentiation and self-renewal.

pancreatic cancer

Cell-cell interactions in early carcinogenesis

This research group focuses on the earliest stages of cancer in epithelial tissues.

Heart shaped crypts from the gut

Understanding the links between diet and cancer

This research group focuses on identifying how dietary components alter the behaviour of normal and cancerous stem cells.

Human squamous cell carcinoma

The Skin Cancer Programme

The Skin Cancer Programme uses skin cancer stem cell models to find new ways to prevent, detect and develop novel therapies for all cancer types.

Brain tumour cells

Astroglia Cell Biology

This research group investigates transcriptional regulation of cell plasticity in normal and transformed astrocytes.

Red blood cells

Blood Stem Cells and Leukaemia: Developmental Signalling and Niche

The Blood Stem Cells and Leukaemia research group studies the regulation of human normal versus malignant blood development.

Co-immunofluorescence for proliferating cells (red) and active Wnt signaling (green) in a small intestinal tumour following treatment with Jak inhibitor.

Cancer and Cell Signalling

The Cancer and Cell Signalling research group investigates the requirement of cell signalling during homeostasis, to identify novel therapeutic targets and strategies for the treatment of cancer.