Tim Jacob

Recent publications

Full Refereed Papers

O’Connor, S. and Jacob, T.J.C. (2007) Neuropharmacology of the olfactory bulb - the emergence of functional processing circuits. Trends in Neuroscience (in review).

Boulkroune, N., Wang, L., March, A., Walker, N. and Jacob, T.J.C. (2007) Repetitive olfactory exposure to the biologically significant steroid androstadienone causes a hedonic shift and gender dimorphic changes in olfactory evoked potentials. Neuropsychopharmacology doi:10.1038/sj.npp.1301303 (online, ahead of publication).

Chen, L., Zhu, L., Jacob, T.J.C., and Wang, L. (2006) Roles of volume-activated Cl- currents and regulatory volume decrease in cell cycle and proliferation in nasopharyngeal carcinoma cells. Cell Proliferation (In press)

Jianwen Mao, Liwei Wang, Aihui Fan, Jianhong Wang, Bin Xu, Tim J. C. Jacob, Lixin Chen (2006) Blockage of Volume-activated Chloride Channels Inhibits Migration of Nasopharyngeal Carcinoma Cells. Cellular Physiology and Biochemistry (in review)

Tim J. C. Jacob and Liwei Wang (2006) A new method for measuring reaction times for odour detection at iso-intensity: comparison between an unpleasant and pleasant odour. Physiology and Behavior. 87(3):500-5.

Tim J.C. Jacob, Liwei Wang, Sajjida Jaffer and Sara McPhee (2006) Changes in the odour quality of androstadienone during exposure-induced sensitization. Chemical Senses 31, 3-8.

Mao JW, Wang LW, Jacob T, Sun XR, Li H, Zhu LY, Li P, Zhong P, Nie SH, Chen LX. (2005) Involvement of regulatory volume decrease in the migration of nasopharyngeal carcinoma cells. Cell Res. May;15(5):371-8.

Wang, L., Hari, C., Chen, L. and Jacob, T.J.C. (2004) A new non-invasive method for recording the electro-olfactogram (EOG) using external electrodes. Clinical Neurophysiology 115(7), 1631-1640.

Wang, L., Chen, L. and Jacob, T.J.C. (2004) Evidence for peripheral plasticity in the human odour response. Journal of Physiology 544, 236-244.

He QF, Wang LW, Mao JW, Sun XR, Li P, Zhong P, Nie SH, Jacob T, Chen LX. (2004) Activation of chloride current and decrease of cell volume by ATP in nasopharyngeal carcinoma cells. Sheng Li Xue Bao. Dec 25;56(6):691-6.

Jacob, T.J.C., Fraser, C., Wang, L., Walker, W.E., and O’Connor, S. “Psychophysical evaluation of responses to pleasant and malodour stimulation in human subjects; adaptation, dose response and gender differences”. International Journal of Psychophysiology (2003) 48, 67-80.

Wang, L., Walker, V.E., Sardi, H., Fraser, C. and Jacob, T.J.C. (2002) The correlation between physiological and psychological responses to odour stimulation in human subjects. Clinical Neurophysiology 113, 542-551.

Chen, L., Wang, L., Zhu, L., Nie, S., Zhang, J., Zhong, P., Cai, B., Luo, H. and Jacob, T.J.C. “Cell cycle dependent expression of volume-activated chloride currents in nasopharyngeal carcinoma cells (CNE-2Z). American Journal of Physiology (2002) 283(4), C1313-C1323.

Wang, L., Chen, L., Zhu, L., Rawle, M., Nie, S., Zhang, J., Zhong, P., Kangrong, C. and Jacob, T.J.C. “Regulatory volume decrease is actively modulated during the cell cycle”. Journal of Cellular Physiology (2002) 193(1), 110-119.

Drake, K.D., Schuette, D., Chepelinsky, A.B., Jacob, T.J.C. and Crabbe, M.J. (2002) pH-dependent channel activity of heterologously-expressed main intrinsic protein (MIP) from rat lens. FEBS Letters 512(1-3), 199-204.

Wang, L., Chen, L. and Jacob, T.J.C. "The role of ClC-3 in volume-activated chloride currents and volume regulation demonstrated by antisense inhibition". Journal of Physiology (2000) 524, 63-75.

Chen, L., Wang, L. and Jacob, T.J.C. "Association of intrinsic pICln with Cl- transport and volume regulation in native non-pigmented ciliary epithelial cells". American Journal of Physiology (1999) 276, C182-C192.

Walker, V.E., Stelling, J.W., Miley, H.E. and Jacob, T.J.C. "Effect of coupling on the volume regulatory responses of ciliary epithelial cells; a possible mechanism for aqueous humour formation". American Journal of Physiology (1999) 276, C1432-C1438.

Wang, L., Chen, L. and Jacob, T.J.C. "Antisense to MDR1 mRNA reduces P-glycoprotein expression, swelling-activated Cl- current and volume regulation in bovine ciliary epithelial cells". Journal of Physiology (1998) 511, 33-44.

Zhang, J.J. and Jacob, T.J.C. "Three different Cl- channels in the bovine ciliary epithelium activated by hypotonic stress". Journal of Physiology (1997) 499.2, 379-389.

Stelling, J.W. and Jacob, T.J.C. "Functional coupling in bovine ciliary epithelial cells is modulated by carbachol". American Journal of Physiology (1997) 273 (6), C1876-C1881.

Mitchell, C.H., Zhang, J.J., Wang, L. and Jacob, T.J.C. " Volume-sensitive chloride current in pigmented ciliary epithelial cells: role of phospholipases". American Journal of Physiology (1997) 272, C212-C222.

Mitchell, C.H., Wang, L. and Jacob, T.J.C. "A large-conductance chloride channel in pigmented ciliary epithelial cells". Journal of Membrane Biology (1997) 158, 167-175.

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Books etc

Jacob, Tim. The Science of Taste and Smell. In "Art and the Senses" eds. Francesca Bacci and David Melcher, Oxford University Press. 2007.

Jacob, T.J.C. “The olfactory system”. Chapter 23 in “Signals and Perception: The Fundamentals of Human Sensation” ed. David Roberts, Palgrave Macmillan, Basingstoke, U.K. 2002.

Jacob, T.J.C. “The gustatory sensory system”. Chapter 25 in “Signals and Perception: The Fundamentals of Human Sensation” ed. David Roberts, Palgrave Macmillan, Basingstoke, U.K. 2002.

Media quotes:

Scientists find sourness detector. BBC News 23 August 2006.

Same taste bud for 'bitter-sweet. BBC News 19 July 2005.

'Taste bud' for fatty foods found. BBC News 2 November 2005.

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Conference abstracts and Talks

1. Jacob, T.J.C., Stelling, J.W., Camodeca, N., Mitchell, C.H. and Walker, V.E. “A new hypothesis for aqueous humour secretion” XXXlll International Congress of Physiological Sciences, IUPS 1997, St Petersberg.
2. Jacob, T.J.C. and Zhang, J.J. “The lens: mechanisms of epithelial and fibre cell function” XXXlll International Congress of Physiological Sciences, IUPS 1997, St Petersberg.
3. Wang, L., Chen, L. and Jacob, T.J.C. “ Antisense knock-down of multidrug resistance mRNA, reduces P-glycoprotein expression, and compromises ICl,vol and regulatory volume decrease in ciliary epithelial cells”. Xlll ICER Conference, Paris. Experimental Eye Research 67 (suppl.1) (1998), S.22.
4. Jacob, T.J.C. “Olfactory evoked potentials?” 27th British Psychophysiological Society Meeting, Institute of Neurology, London, December 1999.
5. Hari, C.K., Wang, L. and Jacob, T.J.C. “Olfactory receptor potential in humans” .. Chemical Senses (2001), 26(6), 790
6. Wang, L., Fraser, C.S. and Jacob, T.J.C. “Characterisation of the perception of the malodours butyric acid and N-valeric acid in humans”. Chemical Senses (2001), 26(6), 790.
7. Wang, L., Chen, L. and Jacob, T.J.C. “Cell volume regulation in the cell cycle of nasopharyngeal carcinoma cells”. Cell Biology International (2001) 25(2), A19.
8. Jacob, T.J.C., Hari, C. and Wang, L. “Simultaneous recording of EOG, OERP and ‘bulbar’ potentials in humans”. Chemical Senses (2001) 26, 1088.
9. Jacob, T.J.C., Fraser, C.S. and Wang, L. “A study of hypoadditivity using dichorhinal stimulation”. Chemical Senses (2002) 27(7), 670, AchemS XXlll A100.
10. Wang, L., Hari, C., Chen, L. and Jacob, T.J.C. “A new non-invasive method for recording the electro-olfactogram (EOG) using external electrodes”. ECRO 2004, Dijon, France. Chemical Senses (2005) 30(2), E18-E19.
11. Wang, L., Chen, L. and Jacob, T.J.C. “Evidence for peripheral plasticity in the human odour response”. ECRO 2004, Dijon, France. Chemical Senses (2005) 30(2), E57-E58.
12. Boulkroune, N, Wang, L., March, A., Walker, N. and Jacob, T.J.C. “Learning to smell androstadienone”. CSiV Chester, July 2006.
13. Jacob, T.J.C. and Boulkroune, N. “Olfactory evoked potentials: usefulness and limitations”. ECRO, Granada, September 2006.
14. Jacob, T.J.C. “The science of taste and smell”. Invited speaker at three day conference on Art and the Senses, Oxford (Sept 2006).
15. Jacob, T.J.C. “Smell and Health”. International Symposium of Aromatherapy and Medicinal Plants, Grasse, France, March 2007.
16. Jacob, T.J.C. “Sniffing skunks and smelly elephants”. Talk at London Zoo (ZSL) as part of National Science Week. March 2007.

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