Major Grant Awards 2012
3 February 2012

Congratulations to the following staff who were awarded major grants during 2012:
>M£1
Prof OH Petersen, Dr OV Gerasimenko, Dr JV Gerasimenko (MRC) Calcium signalling, organelle dysfunction and pancreatitis - £1,425,607
Dr I Durance, Prof SJ Ormerod, Prof MW Bruford, Dr IP Vaughan and Prof AJ Weightman (NERC) Diversity in upland rivers and ecosystem service sustainability - DURESS - £1,115,617
>K£100
Prof OH Petersen (MRC) Ion channels and pumps in secretory cells (additional award) - £837,749
Dr Simon Brooks, Prof Steve Dunnett (with MEDIC) (CHDI Foundation) A comparative study of behavioural, anatomical and molecular changes in mouse models of Huntingdon's Disease - £726,291
Prof JAH Murray, Dr W Dewitte (BBSRC) A novel pathway of cell cycle activation in root formative divisions - £673,682
Prof AJ Weightman, Dr G Webster, Dr P Kille (BIOSI), Prof J Parkes & Dr H Sass (EARTH) (NERC) How are candidate phylum JS1 bacteria adapted for life in the deep sub-seafloor biosphere - £488,351
Prof TC Dale (Merck Serono) Identification of WNT pathway inhibitors (additional funding) - £440,213
Dr RM John (BBSRC) Achieving a successful pregnancy: Epigenetic regulation of fetal-material signalling - £380,792
Dr KD Fox (MRC) The role of DISC1 in synaptic function and circuit formation during critical periods of cortical development - £364,644
Dr Julian Marchesi (BBSRC) A study of metagenomics-informed biochemical functionality of microbial fuel cells using DDGS as a substrate - £354,623
Dr MT Young (BBSRC) The P2X7 interactome: Protein interactions in the P2X7 C-terminus and their role in inflammatory signalling - £330,433
Prof P Borri and Dr P Watson (with PHARMACY) (EPSRC) Laser-guided nanoparticles and cell scalextrics - £305,557
Prof TJC Jacob (Northeast Gast Association) An investigation into the physiological mechanisms of odour cancellation or antagonism that occurs between certain conjugate pairs of odorants and results in masking (additional funding) - £296,791
Prof TC Dale (Nanotether Discovery Science Ltd) Support for the development of Nanotether - £249,323
Prof William Gray (Epilepsy Research UK) Developing targeted pharmaceutical strategies for restoring hippocampal learning in temporal lobe epilepsy - £240,589
Prof AR Clarke (with MEDIC and PHARMACY) (Cancer Research UK Centre - additional funding) - £214,817
Dr B Latinkic (British Heart Foundation) Identification and analysis of genomic programme for cardiac specification - £201,697
Prof CW Archer (BBSRC) Optimising stem cell therapy: investigating clonal heterogeneity in equine chondroprogenitor cells - £200,121
Prof Paul Kemp, Prof Daniela Riccardi and Dr Nick Allen (British Heart Foundation) Mechanism of regulation by erythropoietin of hypoxic signal transduction - £193,845
Dr Matt Smalley (Breast Cancer Campaign) The role of the c-Kit - Lyn kinase signalling network in the biology and transformation of mammary epithelial cells - £193,746
Dr Emyr Lloyd-Evans (Action Medical Research) Translational therapy development for Smith-Lemil-Opitz Syndrome, a common under-diagnose childhood malformation syndrome - £173,809
Dr Richard Clarkson (with Pharmacy) (Breast Cancer Campaign) - Pre-clinical evaluation of TRAIL-hypersensitivity in acquired endocrine resistant breast cancer - £169,456
Dr K Berube (Helmholtz Virtual Institute of Complex Molecular Systems in Environmental Health) Expanding networks within the scientific community - £167,224
Dr HJ Rogers and Dr Carsten Muller (QUAFETY) Comprehensive approach to enhance quality and safety of ready to eat fresh products - £165,274
Dr E Lloyd-Evans (European Commission (FP7)) Targeting common mechanisms of pathogenesis in diseases of sterol homeostasis associated with lysosome dysfunction development of novel and rapidly translatable clinical therapies STEROLOSOMES - £164,304
Prof AR Clarke (with MEDIC) (NISCHR) PET Bio-marker imaging in response to novel target anti-cancer therapy in a clinically applicable model of colon cancer - £163,433
Prof Vincenzo Crunelli (Epilepsy Research UK) Serotoninergic modulation of absense seizures: Focus on tonic GABA - £149,827
Dr P Kille (Environment Agency) Development of a molecular diatom tool for WFD classification of rivers and lakes - £140,000
Prof CW Archer and Dr R Williams (Arthritis Research UK) A method to distinguish and isolate highly potent articular cartilage-derived stem cells - £129,584
Prof TC Dale, Prof P Borri & Prof AJ Harwood (Nanotether Discovery Science Ltd) Development of Nanotether biochemistry - £123,590
Dr B Latinkic (BHF) Investigating the mechanisms of nodal and FGF signalling in cardiac specification - £103,410
