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Gas Chromatography

Standalone GC’s

Three standalone capillary GC’s fitted with FID detection or ECD and split/splitless injection. The instruments are not fitted with autosamplers and have limited computing capacity but are fine for routine analysis of volatiles and semi-volatiles (profiling) or establishing methods before moving on to GC-MS.


One capillary GC is dedicated for simultaneous recording of electrophysiological responses (GC-EAD), which are elicited by the analytes along the FID trace. GC-EAD equipment is only available in a few other places in the UK offering a powerful tool for studies of chemically mediated behaviour in insects and plant — insect interactions in particular.


The unit contains two GC-MS systems both fully automated and fitted with autosamplers and additional sampling devices. Both devices offer electron impact (EI) and chemical ionisation (CI).

MD800 (ThermoFinnigan): robust GC-MS fitted with split/splitless injection port, autosampler and also purge and trap sampler for analysis of volatiles and semi-volatiles from water and aqueous samples (compliant with US EPA).

Agilent MSD: a new system fitted with split/splitless and programmed temperature vaporisation (PTV) port. The PTV injector is also suitable for on-column injection (OC).

Both instruments can be used for a variety of analytes such as pesticides, FAME’s, sulphur compounds (Agilent, on-coulumn), essential oils/terpenes. The availability of on-column and PTV injection allows analysis of thermolabile compounds (OC) and application of diluted samples/large volumes (PTV). Both machines can utilise solid phase micro extraction (SPME) as a very simple sample preparation method, which has been successfully used for the analysis of pesticides from water, semiochemicals and terpenes.

Liquid Chromatography

Three standalone HPLC systems (HP 1090, Dionex, Beckman System Gold) with autosampler and data processing. All units are fitted with UV detection (HP, Dionex) or photo diode array (PDA, Beckmann). The unit provides a selection of chromatographic columns especially designed for analysis of highly polar analytes (e.g. organic acids, small peptides) from aqueous matrices and more standard RP18, SEC and IEC phases. Past analyses have included small peptides, organic acids, pesticides and semio-chemicals. The instruments can operate up to semi-preparative scale but are routinely run at analytical scale.


A ThermoFinnigan Navigator system, together with a ThermoSeparation HPLC system, form the backbone of the LC-MS services. The system is fully automated and offers the latest LC-MS software. Its performance has been greatly improved by the recent purchase of a PDA detector and continuous nitrogen supply. The instrument offers electrospray ionsation (ESI) and atmospheric pressure chemical ionisation (ApCI). Most organic molecules are susceptible to either of these modes, proteins and peptides more notably to ESI. The instrument offers an analytical solution for a variety of non-volatile low and high molecular weight analytes e.g. profiling of peptides, complex lipids.


BIOSI staff may view a price list of our charges on the web page INSIDE BIOSI. Charges to external users are available on request.

For further information:

Dr Carsten Müller

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Telephone: +44 (0)29 208 75263Extension: 75263

Mr Michael O'Reilly

Position:Senior Technician
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Telephone: +44(0)29 208 75273Extension: 75273