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Dr Mark Young 


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Link to ScopusTM Database

Selected Publications

  1. Roberts JA, Allsopp RC, El Ajouz S, Vial C, Schmid R, Young MT and Evans RJ (2012) Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel. Proc Natl Acad Sci USA 109: 4663-7.
  2. Valente M, Watterson SJ, Parker MD, Ford RC and Young MT (2011) Expression, purification, electron microscopy, N-glycosylation mutagenesis and molecular modeling of human P2X4 and Dictyostelium discoideum P2XA. Biochim Biophys Acta 1808: 2859-66.
  3. Fujii K, Young MT and Harris KD (2011) Exploiting powder X-ray diffraction for direct structure determination in structural biology: the P2X4 receptor trafficking motif YEQGL. J Struct Biol 174: 461-7.
  4. Young MT (2010) P2X receptors: dawn of the post-structure era. Trends Biochem Sci 35: 83-90.
  5. Cao L, Broomhead HE, Young MT and North RA (2009) Polar residues in the second transmembrane domain of the rat P2X2 receptor that affect spontaneous gating, unitary conductance, and rectification. J Neurosci 29: 14257-64.
  6. Young MT, Zhang YH, Cao L, Broomhead H and Jiang LH (2008) Role of the domain encompassing Arg304-Ile328 in rat P2X2 receptor conformation revealed by alterations in complex glycosylation at Asn298. Biochem J 416: 137-43.
  7. Young MT, Fisher JA, Fountain SJ, Ford RC, North RA and Khakh BS (2008) Molecular shape, architecture, and size of P2X4 receptors determined using fluorescence resonance energy transfer and electron microscopy. J Biol Chem 283: 26241-51.
  8. Young MT, Pelegrin P and Surprenant A (2007) Amino acid residues in the P2X7 receptor that mediate differential sensitivity to ATP and BzATP. Mol Pharmacol 71: 92-100.
  9. Fountain SJ, Parkinson K, Young MT, Cao L, Thompson CR and North RA (2007) An intracellular P2X receptor required for osmoregulation in Dictyostelium discoideum. Nature 448: 200-3.
  10. Cao L, Young MT, Broomhead HE, Fountain SJ and North RA (2007) Thr339-to-serine substitution in rat P2X2 receptor second transmembrane domain causes constitutive opening and indicates a gating role for Lys308. J Neurosci 27: 12916-23.
  11. Young MT, Pelegrin P and Surprenant A (2006) Identification of Thr283 as a key determinant of P2X7 receptor function. Br J Pharmacol 149: 261-8.
  12. Sim JA, Chaumont S, Jo J, Ulmann L, Young MT, Cho K, Buell G, North RA and Rassendren F (2006) Altered hippocampal synaptic potentiation in P2X4 knock-out mice. J Neurosci 26: 9006-9.
  13. Sim JA, Young MT, Sung HY, North RA and Surprenant A (2004) Reanalysis of P2X7 receptor expression in rodent brain. J Neurosci 24: 6307-14.