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Dr Andrew Shore 

Silencing of Uncoupling Protein 1 Expression

Uncoupling Protein 1 (UCP1) uncouples the respiratory chain from ATP Synthase by providing an alternative route for protons to cross the inner mitochondrial membrane. When this route is activated large quantities of heat are produced at the expense of ATP. UCP1 is specific to brown adipose tissue. In humans brown adipose tissue is only found in neonates for whom it is vital to maintain their body temperature. Thermogenically active brown adipose tissue consumes more energy than any other tissue, if transcription and activation of this protein could be easily manipulated in adults it may provide an important treatment to combat obesity and the metabolic syndrome. New evidence suggests that DNA methylation and chromatin remodelling may play a key role in regulating UCP1 expression. Although murine models are widely used to study UCP1 expression, epigenetic control of the gene may be significantly different in humans making findings difficult to transfer to humans. Recent research has focussed on identifying and validating more appropriate models for epigenetic regulation of UCP1 transcription in humans.

Allied collaborative research projects have included regulation of gene silencing by RIP140 and the role of gene silencing in tumour formation in mouse models for adenoviral gene therapy.

Pedagogic Research

Current pedagogic research interests span medical and bioscience education and focus on managing the student experience, particularly in the transition from level 3 to level 4 upon entering higher education. This research often involves the role that learning technology can play to engage students and develop their study skills as well as their subject specific knowledge. Current projects involve:

  • The use of technology to engage learners in large and small group contexts
  • Using learning technology for formative assessment
  • Transition of learners from level 3 to level 4 – study skills development
  • The impact of elective feedback
  • The performance and experience of vocational learners in Higher Education
Recent Research Presentations

Engaging students through questioning. QUILT Technology Enhanced Education Conference 2010, Cardiff.

Innovative uses of an audience response system for formative assessment & student directed lectures. STEM Network SW, July 2009.

Using VLE directed physiology practicals & data loggers to improve student learning. STEM Summer School SW, July 2009.

Front loading of practicals via a VLE icreases student engagement and maximises practical teaching time. STEM Network SW, March 2009.

Embedding an audience response system for formative assessment: the effect on VLE engagement. Education Enhancement Conference 2009, Bournemouth.

Tissue specific expression of Uncoupling Protein 1 is determined by DNA methylation. European Congress on Obesity 2007, Budapest.

Recent grants have been awarded from:

Development fund for technology enhanced education – Cardiff University (2010)


LSIS (2009)

Collaborative research fund - Bournemouth University (2009)