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Dr Karen Reed 

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Selected Publications

Feng GJ, Cotta W, Wei XQ, Poetz O, Evans R, Jardé T, Reed K, Meniel V, Williams GT, Clarke AR, Dale TC (2012) Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice Gastroenterology 143(6):1650-9

Reed KR, Tunster SJ, Young M, Carrico A, John RM, Clarke AR (2011) Entopic over-expression of Ascl2 does not accelerate tumourigenesis in APCmin mice Gut 61(10):1435-1438

Kant P, Sainsbury A, Reed KR, Pollard SG, Scott N, Clarke AR, Coletta PL, Hull MA (2011) Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB Gut 60(7):893-901

Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ (2010) Cyclin D2-Cyclin-Dependent Kinase 4/6 Is Required for Efficient Proliferation and Tumorigenesis following Apc Loss Cancer Research 70(20):8149-8158

Burke ZD, Reed KR, Phesse TJ, Sansom OJ, Clarke AR, Tosh D (2009) Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism Gastroenterology 136(7):2316-2324

Karen R Reed, Dimitris Athineos, Valerie S Meniel, Julie A Wilkins, Rachel A Ridgway, Zoé D. Burke, Vanesa Muncan, Alan R Clarke, Owen J  Sansom (2008) B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of Apc loss in the liver PNAS 105(48):18919-23s

Phesse TJ, Parry L, Reed KR, Ewan KB, Dale TC, Sansom OJ, Clarke AR.(2008) Deficiency of Mbd2 attenuates Wnt signaling Mol Cell Biol. 28:6094-103

Reed KR, Meniel VS, Marsh V, Cole A, Sansom OJ, Clarke AR.(2008) A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine. BMC Cancer, 8:162. “Highly accessed article”

Sansom OJ, Meniel VS, Muncan V, Phesse TJ, Wilkins JA, Reed KR, Vass JK, Athineos D, Clevers H, Clarke AR.(2007) Myc deletion rescues Apc deficiency in the small intestine Nature 446:676-9

Reed KR, Sansom OJ, Hayes AJ, Gescher AJ, Peters JM and Clarke AR.(2006) PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.BMC Cancer, 6:113

Sansom OJ, Griffiths DFR, Reed KR, Winton DJ and Clarke AR (2005) Apc Deficiency Predisposes to Renal Carcinoma in the Mouse Oncogene 24:8205-10

Sansom OJ, Reed KR, van de Wetering M, Muncan V, Winton DJ, Clevers H and Clarke AR (2005) Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine J Biol. Chem 280:28463-7

Reed KR, Sansom OJ, Hayes AJ, Gescher AJ, Winton DJ, Peters JM and Clarke AR (2004) PPARdelta status and Apc mediated tumourigenesis in the mouse intestine Oncogene 23:8992-6

Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP, Batlle E, Simon-Assmann P, Clevers H, Nathke IS, Clarke AR and Winton DJ (2004) Loss of Apc immediately perturbs differentiation and migration in the small intestine Genes and Development 18:1385-1390

Cerrato F, Dean W, Davies K, Kagotani K, Mitsuya K, Okumura K, Riccio A, Reik W (2003) Paternal imprints can be established on the maternal Igf2-H19 locus without altering replication timing of DNA Human Molecular Genetics 12(23):3123-32

Davies K, Bowden L, Smith P, Dean W, Hill D, Furuumi H, Sasaki H, Cattanach B, Reik W (2002) Disruption of mesodermal enhancers for Igf2 in the minute mutant Development 129(7):1657-68

Paulsen M, El-Maarri O, Engemann S, Strodicke M, Franck O, Davies K, Reinhardt R, Reik W, Walter J (2000) Sequence conservation and variability of imprinting in the Beckwith-Wiedemann syndrome gene cluster in human and mouse Human Molecular Genetics 9(12):1829-41

Reik W, Constancia M, Dean W, Davies K, Bowden L, Murrell A, Feil R, Walter J, Kelsey G (2000) Igf2 imprinting in development and disease Int J Dev Biol 44(1):145-50

Contributions to compiled volumes

Reik W, Davies K, Dean W, Kelsey G, Constancia M (2001) Imprinted genes and the coordination of fetal and postnatal growth in mammals Novartis Found Symp. 237:19-31; discussion 31-42.