Prof Meng Li
Location:Cardiff School of Biosciences, Hadyn Ellis Building, Maindy Road, Cathays Cardiff CF24 4HQ
Our group is interested in elucidating the molecular mechanisms underlining neural fate specification and the subsequent differentiation of neuroectoderm cells into defined neuronal subtypes. We aim to exploit iPSC-derived neurons for elucidating the cellular basis of neuropsychiatric diseases and developing better strategies for cell therapies. We employ an integrated experimental approach involving in vitro neural development of human and mouse embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), as well as contemporary genetic manipulation in model organisms. We apply the resulting knowledge to devise novel strategies that drive pluripotent stem cells into clinically important neurons, such as midbrain dopamine neuron, striatal GABAergic neurons and cortical interneurons.