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Dr Rosalind John  -  PhD

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Link to ScopusTM Database

Recent Publications 

Peer reviewed research articles

Characterization of DNA methylation errors in patients with imprinting disorders conceived by assisted reproduction technologies. Hiura H, Okae H, Miyauchi N, Sato F, Sato A, Van De Pette M, John RM, Kagami M, Nakai K, Soejima H, Ogata T, Arima T. Hum Reprod 2012 Aug; 27(8):2541-8. Jun 6.

Impact of genetic background on placental glycogen storage in mice. Tunster SJ, Van de Pette M, John RM. Placenta 2012 Feb; 33(2):124-7

Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass. Lewis RM, Cleal JK, Ntani G, Crozier SR, Mahon PA, Robinson SM, Harvey NC, Cooper C, Inskip HM, Godfrey KM, Hanson MA; Southampton Women's Survey Study Group, John RM Bone 2012 Jan; 50(1):337-42

Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Reed KR, Tunster SJ, Young M, Carrico A, John RM, Clarke AR Gut 2011 Dec 3; 61(10):1435-1438

Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome. Tunster SJ, Van de Pette M, John RM. Dis Model Mech. 2011 Nov; 4(6):814-21

A tripartite paternally methylated region within the Gpr1-Zdbf2 imprinted domain on mouse chromosome 1 identified by meDIP-on-chip. Hiura H, Sugawara A, Ogawa H, John RM, Miyauchi N, Miyanari Y, Horiike T, Li Y, Yaegashi N, Sasaki H, Kono T, Arima T. Nucleic Acids Res 2010 Aug; 38(15):4929-45

Autonomous silencing of the imprinted Cdkn1c gene in stem cells. Wood MD, Hiura H, Tunster S, Arima T, Shin JY, Higgins M, John RM Epigenetics 2010 Apr 22; 5(3)

The imprinted Phlda2 gene regulates extraembryonic energy stores. Tunster SJ, Tycko B, John RM. Mol Cell Biol 2010 Jan; 30(1):295-306

DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm. Kobayashi H, Hiura H, John RM, Sato A, Otsu E, Kobayashi N, Suzuki R, Suzuki F, Hayashi C, Utsunomiya T, Yaegashi N, Arima T. Eur J Hum Genet 2009 Dec; 17(12):1582-91.

Peer reviewed reviews/book chapters

Epigenetic regulation of placental endocrine lineages and complications of pregnancy. John, R. M. Biochem Soc Trans. 2013 Jun;41(3):701-9.

Imprinted genes in mouse placental development and the regulation of fetal energy stores. Tunster, S. J.; Jensen, A. B. and John, R. M. Reproduction. 2013 Apr 29;145(5):R117-37.

'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care. Clarke AJ, Cooper DN, Krawczak M, Tyler-Smith C, Wallace HM, Wilkie AO, Raymond FL, Chadwick R, Craddock N, John R, Gallacher J, Chiano M. Hum Genomics. 2012 Aug 2;6:11.

A placenta for life. John RM and Hemberger M. Repoductive BioMedicine Online 2012 April 5. Review.

IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells. Ackerman WE 4th, Bulmer JN, Carter AM, Chaillet JR, Chamley L, Chen CP, Chuong EB, Coleman SJ, Collet GP, Croy BA, de Mestre AM, Dickinson H, Ducray J, Enders AC, Fogarty NM, Gauster M, Golos T, Haider S, Heazell AE, Holland OJ, Huppertz B, Husebekk A, John RM, Johnsen GM, Jones CJ, Kalionis B, König J, Lorenzon AR, Moffett A, Moreira de Mello JC, Nuzzo AM, Parham P, Parolini O, Petroff MG, Pidoux G, Ramírez-Pinilla MP, Robinson WP, Rolfo A, Sadovsky Y, Soma H, Southcombe JH, Tilburgs T, Lash GE.  Placenta. 2012 Feb; 33 Suppl:S15-22. Meeting report.

Developmental regulation of somatic imprints. John RM, Lefebvre L. Differentiation 2011 Jun; 81(5):270-80. Epub 2011 Feb 11. Review.

BACs as tools for the study of genomic imprinting. Tunster SJ, Van De Pette M, John RM. J Biomed Biotechnol. 2011; 2011:283013 Review.

Engineering mouse models to investigate the function of imprinting. John RM Brief Funct Genomics 2010 Jul; 9(4):294-303 Review.

Benjamin Tycko and Rosalind John (2010). “The role of imprinted genes in placental growth: implications for the developmental origins of health and disease.” In “The Role of Placentation in Developmental Programming”, edited by Prof. Graham Burton, Cambridge University Press. Book chapter.

Previous selected publications 

Kobayashi H, Hiura H, John RM, Sato A, Otsu E, Kobayashi N, Suzuki R, Suzuki F, Hayashi C, Utsunomiya T, Yaegashi N and Arima T (2009) DNA methylation errors at imprinted loci after assisted conception originate in the parental sperm. European Journal of Human Genetics 17(12):1582-91. Sowpati DT, 

Thiagarajan D, Sharma S, Sultana H, John RM, Surani A, Mishra RK and Khosla S (2008) An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila. Mechanisms of Development 125(11-12):963-73

Andrews S, Wood M, Tunster S, Barton SC, Surani MA and John RM (2007) Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7. BMC Developmental Biology 7(1):53 

Arima T, Yamasaki K, John RM, Kato K, Sakumi K, Nakabeppu Y, Wake N and Kono T (2006) The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice Genomics 88(5):650-658

Azuara V, Perry P, Sauer S, Spivakov M, Jørgensen HF, John RM, Gouti M, Casanova M, Warnes G, Merkenschlager M and Fisher AG (2006) Chromatin signatures of pluripotent cell lines Nature Cell Biology 8(5):532-8.