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Prof Robert Huber 

Link to ScopusTM Database

My interests centre on the understanding of the structure and function of biological macromolecules. My work has included studies on proteases and their natural and synthetic inhibitors, metalloenzymes (iron, nickel, molybdenum, copper), proteins of the immune system (antibodies and antibody receptors), protein hormones and their receptors, protein kinases, enzymes of amino acid biosynthesis, enzymes of cofactor and vitamin biosynthesis and proteins of energy and electron transfer. In addition, I am interested in the development of instrumentation for data collection and of methods in protein crystallography, ranging from Patterson methods, graphic methods, and refinement, to the use of electron rich metal clusters, and most recently to the methods and instruments for crystal improvement.

Schneider, E.V., Böttcher, J., Huber, R., Maskos, K., Neumann, L. (2013) Structure-kinetic relationship study of CDK8/CycC specific compounds Proceedings of the National Academy of Sciences of the United States of America, 110 (20), pp. 8081-8086.

Baek, S., Kang, N.J., Popowicz, G.M., Arciniega, M., Jung, S.K., Byun, S., Song, N.R., Heo, Y.-S., Kim, B.Y., Lee, H.J., Holak, T.A., Augustin, M., Bode, A.M., Huber, R., Dong, Z., Lee, K.W. (2013)Structural and functional analysis of the natural JNK1 inhibitor quercetagetin Journal of Molecular Biology, 425 (2), pp. 411-423.

Huber, R. (2013) How I Chose Research on Proteases or, More Correctly, How it Chose Me Angewandte Chemie - International Edition, 52 (1), pp. 68-73.

Tennstaedt, A., Pöpsel, S., Truebestein, L., Hauske, P., Brockmann, A., Schmidt, N., Irle, I., Sacca, B., Niemeyer, C.M., Brandt, R., Ksiezak-Reding, H., Tirniceriu, A.L., Egensperger, R., Baldi, A., Dehmelt, L., Kaiser, M., Huber, R., Clausen, T., Ehrmanna, M. (2012)Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates Journal of Biological Chemistry, 287 (25), pp. 20931-20941.

Weski, J., Meltzer, M., Spaan, L., Mönig, T., Oeljeklaus, J., Hauske, P., Vouilleme, L., Volkmer, R., Boisguerin, P., Boyd, D., Huber, R., Kaiser, M., Ehrmann, M. (2012) Chemical biology approaches reveal conserved features of a C-terminal processing PDZ protease ChemBioChem, 13 (3), pp. 402-408.

Baek, S., Kutchukian, P.S., Verdine, G.L., Huber, R., Holak, T.A., Lee, K.W., Popowicz, G.M. (2012)Structure of the stapled p53 peptide bound to Mdm2 Journal of the American Chemical Society, 134 (1), pp. 103-106.

Gallastegui, N., Beck, P., Arciniega, M., Huber, R., Hillebrand, S., Groll, M. (2012) Hydroxyureas as noncovalent proteasome inhibitors Angewandte Chemie - International Edition, 51 (1), pp. 247-249.

Sitar, T., Gallinger, J., Ducka, A.M., Ikonen, T.P., Wohlhoefler, M., Schmoller, K.M., Bausch, A.R., Joel, P., Trybus, K.M., Noegel, A.A., Schleicher, M., Huber, R., Holak, T.A. (2011) Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly Proceedings of the National Academy of Sciences of the United States of America, 108 (49), pp. 19575-19580.

Merdanovic, M., Clausen, T., Kaiser, M., Huber, R., Ehrmann, M. (2011) Protein quality control in the bacterial periplasm Annual Review of Microbiology, 65, pp. 149-168.

Schneider, E.V., Böttcher, J., Blaesse, M., Neumann, L., Huber, R., Maskos, K. (2011) The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder Journal of Molecular Biology, 412 (2), pp. 251-266.

Clausen, T., Kaiser, M., Huber, R., Ehrmann, M. (2011) HTRA proteases: Regulated proteolysis in protein quality control Nature Reviews Molecular Cell Biology12 (3), pp. 152-162.

Gallastegui, N., Stein, M., Schmidt, B., Kloetzel, P.-M., Huber, R., Groll, M. (2011) Elucidation of the α-keto-aldehyde binding mechanism: A lead structure motif for proteasome inhibition Angewandte Chemie - International Edition, 50 (2), pp. 542-544.

Groll, M., Gallastegui, N., Maréchal, X., Le Ravalec, V., Basse, N., Richy, N., Genin, E., Huber, R., Moroder, L., Vidal, J., Reboud-Ravaux, M. (2010) 20S proteasome inhibition: Designing noncovalent linear peptide mimics of the natural product TMC-95A ChemMedChem, 5 (10), pp. 1701-1705.

Fernandes, A.T., Damas, J.M., Todorovic, S., Huber, R., Baratto, M.C., Pogni, R., Soares, C.M., Martins, L.O. (2010) The multicopper oxidase from the archaeon Pyrobaculum aerophilum shows nitrous oxide reductase activity FEBS Journal, 277 (15), pp. 3176-3189. 

Merdanovic, M., Mamant, N., Meltzer, M., Poepsel, S., Auckenthaler, A., Melgaard, R., Hauske, P., Nagel-Steger, L., Clarke, A.R., Kaiser, M., Huber, R., Ehrmann, M. (2010) Determinants of structural and functional plasticity of a widely conserved protease chaperone complex Nature Structural and Molecular Biology, 17 (7), pp. 837-843.

Krojer, T., Sawa, J., Huber, R., Clausen, T. (2010) HtrA proteases have a conserved activation mechanism that can be triggered by distinct molecular cues Nature Structural and Molecular Biology, 17 (7), pp. 844-852.

Clerc, J., Schellenberg, B., Groll, M., Bachmann, A.S., Huber, R., Dudler, R., Kaiser, M. (2010) Convergent synthesis and biological evaluation of syringolin a and derivatives as eukaryotic 20S proteasome inhibitors European Journal of Organic Chemistry, (21), pp. 3991-4003.

Ducka, A.M., Joel, P., Popowicz, G.M., Trybus, K.M., Schleicher, M., Noegel, A.A., Huber, R., Holak, T.A., Sitar, T. (2010) Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation Proceedings of the National Academy of Sciences of the United States of America, 107 (26), pp. 11757-11762.

Hasenbein, S., Meltzer, M., Hauske, P., Kaiser, M., Huber, R., Clausen, T., Ehrmann, M. (2010) Conversion of a regulatory into a degradative protease Journal of Molecular Biology, 397 (4), pp. 957-966.

Clerc, J., Florea, B.I., Kraus, M., Groll, M., Huber, R., Bachmann, A.S., Dudler, R., Driessen, C., Overkleeft, H.S., Kaiser, M. (2009) Syringolin A selectively labels the 20S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines ChemBioChem, 10 (16), pp. 2638-2643

Groll, M., Schellenberg, B., Bachmann, A.S., Archer, C.R., Huber, R., Powell, T.K., Lindow, S., Kaiser, M., Dudler, R. (2008) A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism Nature, 452 (7188), pp. 755-758