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Prof John Harwood  -  PhD, DSc

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Link to ScopusTM Database

Selected Publications

Harwood JL, Ramli US, Tang M, Quant PA, Weselake RJ, Fawcett T, Guschina I (2013) Regulation and enhancement of lipid accumulation in oil crops: The use of metabolic control analysis for informed genetic manipulation Eur. J. Lipid Sci. Technol 115 in press

Balogh, G., Péter, M., Glatz, A., Gombos, I., Török, Z., Horváth, I., Harwood, J.L., Vígh, L. (2013) Key role of lipids in heat stress management FEBS Letters, 587 (13), pp. 1970-1980

Harwood, J.L., Guschina, I.A. (2013) Regulation of lipid synthesis in oil crops FEBS Letters, 587 (13), pp. 2079-2081

Tang M, Guschina IA, O'Hara P, Slabas AR, Quant PA, Fawcett T, Harwood JL (2012) Metabolic control analysis of developing oilseed rape (Brassica napus cv Westar) embryos shows that lipid assembly exerts significant control over oil accumulation New Phytologist, 196(2):414-26

Horváth, I., Glatz, A., Nakamoto, H., Mishkind, M.L., Munnik, T., Saidi, Y., Goloubinoff, P., Harwood, J.L., Vigh, L.(2012) Heat shock response in photosynthetic organisms: Membrane and lipid connections Progress in Lipid Research, 51 (3), pp. 208-220

Hemmerlin, A., Harwood, J.L., Bach, T.J. (2012) A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis? Progress in Lipid Research, 51 (2), pp. 95-148.

McLaren, J.E., Michael, D.R., Guschina, I.A., Harwood, J.L., Ramji, D.P.(2011) Eicosapentaenoic acid and docosahexaenoic acid regulate modified LDL uptake and macropinocytosis in human macrophages Lipids, 46 (11), pp. 1053-1061.

Fuschino, J.R., Guschina, I.A., Dobson, G., Yan, N.D., Harwood, J.L., Arts, M.T.(2011)Rising water temperatures alter lipid dynamics and reduce n-3 essential fatty acid concentrations in scenedesmus obliquus (chlorophyta) Journal of Phycology, 47 (4), pp. 763-774.

Balogh, G., Maulucci, G., Gombos, I., Horváth, I., Török, Z., Péter, M., Fodor, E., Páli, T., Benko, S., Parasassi, T., de Spirito, M., Harwood, J.L., Vígh, L.(2011)Heat stress causes spatially-distinct membrane re-modelling in K562 leukemia cells PLoS ONE, 6 (6), art. no. e21182, .

Balogh G, Peter M, Liebisch G, Horvath I, Torok Z, Nagy E, Maslyanko A, Benko S, Schmitz G, Harwood JL and Vigh L (2010) Lipidomics reveals membrane lipid remodelling and release of potential lipid mediators during early stress responses in a murine melanoma cell line. Biochimica et Biophysica Acta 1801:1036-1047.

Harwood JL (2010) Plant fatty acid synthesis. The AOCS Lipid Library (

Hurst S, Rees SG, Randerson PF, Caterson B and Harwood JL (2009) Contrasting effects of n-3 and n-6 fatty acids on cyclooxygenase-2 in model systems for arthritis. Lipids 44:889-896.

Ramli US, Salas JJ, Quant PA and Harwood JL (2009) Use of metabolic control analysis to give quantitative information on control of lipid biosynthesis in the important oil crop, Elaeis guineensis(oilpalm). New Phytologist 184:330-339. *This publication was given the MPOB 2009 best publication award

Zainal Z, Longman AJ, Hurst S, Duggan K, Caterson CE, Hughes CE and Harwood JL (2009) Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis. Osteoarthritis and Cartilage 17:882-891.

Harwood JL and Guschina IA (2009) The versatility of algae and their lipid metabolism. Biochimie 91:679-684. *This publication received an Elsevier most downloaded award in 2010.

Stefanoudaki E, Williams M, Chartzoulakis K and Harwood J (2009) Olive oil qualitative parameters after orchard irrigation with saline water. Journal of Agricultural and Food Chemistry 57(4):1421-1425.

Jackson SK, Abate W, Parton J, Jones S and Harwood JL (2008) Lysophospholipid metabolism facilitates Toll-like receptor 4 membrane translocation to regulate the inflammatory response. Journal of Leukocyte Biology 84:86-92.

Weselake RJ, Shah S, Tang M, Quant PA, Snyder CL, Furukawa-Stoffer TL, Zhu W, Taylor DC, Zou J, Kumar A, Hall L, Laroche A, Rakow G, Raney P, Moloney MM and Harwood JL (2008) Metabolic control analysis is helpful for informed genetic manipulation of oilseed rape (Brassica napus) to increase seed oil content. Journal of Experimental Botany 59:3543-3549.

Hernandez ML, Guschina IA, Martínez-Rivas JM, Mancha M and Harwood JL (2008) The utilisation and desaturation of oleate and linoleate during glycerolipid biosynthesis in olive (Olea europaea L.) callus cultures. Journal of Experimental Botany 59(9):2425-2435.

Vigh L, Horváth I, Maresca B and Harwood JL (2007) Can the stress protein response be controlled by `membrane-lipid therapy? Trends in Biochemical Sciences 32:357-363.

Gunstone FD, Harwood JL and Kijkstra A (eds.) (2007) The Lipid Handbook, 3rd edition, Taylor and Francis, Boca Raton, FL, 791pp.

Sayanova O, Haslam R, Guschina I, Lloyd D, Christie WW, Harwood JL and Napier JA (2006) A bi-functional delta12, delta15-desaturase from Acanthamoeba castellanii directs the synthesis of highly unusual n-1 series unsaturated fatty acids. Journal of Biological Chemistry 281:36533 – 36541.

Vigh L, Escriba PV, Sonnleitner A, Sonnleitner M, Piotto S, Maresca B, Horvath I and Harwood JL (2005) The significance of lipid composition for membrane activity: new concepts and ways of assessing function. Progress in Lipid Research 44:303-344.

Jones SM, Urch JE, Brun R, Harwood JL, Berry C and Gilbert IH (2004) Analogues of thiolactomycin as potential anti-malarial and anti-trypanosomal agents. Bioorganic & Medicinal Chemistry 12:683–692.  *This publication was given an Elsevier most cited paper (2003-2006) award

Roy AB, Hewlins MJE, Ellis AJ, Harwood JL and White GF (2003) Glycolytic breakdown of sulfoquinovose in bacteria: a missing link in the sulphur cycle.  Applied and Environmental Microbiology 69:6434-6441.