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Dr Kenneth Ewan 


RESEARCH PAPERS FROM 2000

1) Ewan K., Pajak B, Stubbs M, Todd H, Barbeau O, Quevedo C, Botfield H, Young R, Ruddle R, Samuel L, Battersby A, Raynaud F, Allen N, Wilson S, Latinkic B, Workman P, McDonald E, Blagg J, Aherne W and Dale T. (2010): A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription. Cancer Res. 70, 5963-7. 


2) Phesse, T.J., Parry, L., Reed, K.R., Ewan, K.B., Dale. T.C., Sansom, O.J. and Clarke, A.R. (2008): Deficiency of Mbd2 attenuates Wnt signaling. Mol Cell Biol. 28, 6094-103.


3) Shimshoni, J.A., Dalton, E.C., Jenkins, A., Eyal, S., Ewan, K., Williams, R.S., Pessah, N., Yagen, B., Harwood, A.J. and Bialer M. (2007): The effects of central nervous system-active valproic acid constitutional isomers, cyclopropyl analogs, and amide derivatives on neuronal growth cone behavior. Mol Pharmacol. 71, 884-92.


4) Smalley, M.J., Signoret, N., Robertson, D., Tilley, A., Hann, A., Ewan, K., Ding, Y., Paterson, H. and Dale, T.C. (2005): Dishevelled (Dvl-2) activates canonical Wnt signalling in the absence of cytoplasmic puncta. J Cell Sci. 118,5279-89.


5) Ewan, K.B., Oketch-Rabah, H.A., Ravani, S.A., Shyamala, G., Moses, H.L and Barcellos-Hoff, M.H. (2005): Proliferation of estrogen receptor-alpha-positive mammary epithelial cells is restrained by transforming growth factor-beta1 in adult mice. Am J Pathol. 167, 409-17.


6) Ewan K.B., Henshall-Powell, R.L., Ravani, S.A., Pajares, M.J., Arteaga, C., Warters, R., Akhurst, R.J. and Barcellos-Hoff M.H. (2002): Transforming Growth Factor-beta1 Mediates Cellular Response to DNA Damage in Situ. Cancer Res. 62, 5627-31.


7) Ewan, K.B., Shyamala, G., Ravani, S.A., Tang, Y, Akhurst, R., Wakefield, L. and Barcellos-Hoff, M.H. (2002): Latent TGF-beta activation in mammary gland: Regulation by ovarian hormones affects ductal and alveolar proliferation. Am. J Pathol. 160, 2081-93.

REVIEWS FROM 2000

1) Ewan K.B. and Dale T.C. (2008): The potential for targeting oncogenic WNT/beta-catenin signaling in therapy. Curr. Drug Targets. 9, 532-47 .


2) Barcellos-Hoff M.H. and Ewan K.B. (2000): Transforming growth factor-beta and breast cancer: Mammary gland development. Breast Cancer Res. 2, 92-9.