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Prof Steve Dunnett 


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Selected Publications

2013

Barker RA, Mason SL, Harrower TP, Swain RA, Ho AK, Sahakian BJ, Mathur R, Elneil S, Thornton S, Hurrelbrink C, Armstrong RJ, Tyers P, Smith E, Carpenter A, Piccini P, Tai YF, Brooks DJ, Pavese N, Watts C, Pickard JD, Rosser AE & Dunnett SB (2013). The long term safety and efficacy of bilateral transplantation of human fetal striatal tissue in patients with mild to moderate Huntington’s disease. J Neurol Neurosurg Psychiat 84(6): 657-665.

Breger LS, Dunnett SB & Lane EL (2013). Comparison of rating scales used to evaluate L-DOPA-induced dyskinesia in the 6-OHDA lesioned rat. Neurobiol Dis 50: 142-150.

Delli Carri A, Onorati M, Castiglioni V, Faedo A, Cattaneo E, Spaiardi P, Biella G, Lelos MJ, Dunnett SB, Rocio R & Barker RA (2013). Developmentally coordinated extrinsic signals drive human pluripotent stem cells differentiation towards fully functional DARPP-32+ medium-sized spiny neurons. Development 140: 301-312.

Harrison DJ, Busse M, Rosser AE, Dunnett SB & Brooks SP (2013). Exercise improves cognition and attenuates neuropathology in a Huntington’s disease mouse model. Exp. Neurol 248: 457-469.

Heuer A, Lelos MJ, Kelly CM, Torres EM & Dunnett SB (2013). Dopamine-rich grafts alleviate deficits in contralateral response space induced by extensive dopamine depletion in rats. Exp Neurol. 247: 485-495.

Heuer A, Vinh NN & Dunnett SB (2013). Behavioural recovery on simple and complex tasks by means of cell replacement therapy in unilateral 6-OHDA lesioned mice. Eur J Neurosci 37(10): 1691-1704.

Klein A, Lane EL & Dunnett SB (2013) Brain repair in a unilateral rat model of Huntington's disease: new insights into impairments and restoration of forelimb movement patterns. Cell Transplant 22(10): 1735-1751.

Rath A, Klein A, Papazoglu A, Pruszak J, Garcia J, Krause M, Maciaczyk J, Dunnett SB & Nikkhah G (2013). Survival and functional restoration of human fetal ventral mesencephalon following transplantation in a rat model of Parkinson’s disease. Cell Transplant 22(7): 1281-1293.

2012

Dunnett SB & Björklund A, eds. (2012) Functional Neural Transplantation III, Part 1. Prog Brain Res, Volume 200. Elsevier, London and Amsterdam.

Dunnett SB & Björklund A, eds. (2012) Functional Neural Transplantation III, Part 2. Prog Brain Res, Volume 201. Elsevier, London and Amsterdam.

Brooks SP, Jones L & Dunnett SB, eds. (2012). Behavioural, Anatomical and Genetic Characterisation of Mouse and Rat Models of Huntington’s Disease. Special Issue of Brain Research Bulletin, pp. 81-284.

Corbett A, Pickett J, Burns A, Corcoran J, Dunnett SB, Edison P, Hagan J, Holmes C, Jones E, Katona C, Kearns I, Kehoe P, Mudher A, Passmore P, Shepherd N, Walsh F & Ballard C (2012). Drug repositioning for Alzheimer’s disease. Nat Rev Drug Disc 11: 833-846 (IF 29.008).

Heuer A, Smith GA, Lelos M, Lane EL & Dunnett SB (2012) Unilateral nigrostriatal 6-hydroxydopamine lesions in mice. I. Behavioural assessment of unilateral striatal dopamine depletion via three different lesion sites. Behav Brain Res. 228: 30-43.

Smith GA, Heuer A, Dunnett SB & Lane EL (2012). Unilateral nigrostriatal 6-hydroxydopamine lesions in mice. II. Predicting L-DOPA-induced dyskinesia. Behav Brain Res. 226: 282-292.

Smith GA, Breger L, Lane EL & Dunnett SB (2012). Pharmacological modulation of amphetamine-induced dyskinesia in transplanted hemi-parkinsonian rats. Neuropharmacology 63(5): 818-828.

Klein A, Sacrey L, Whishaw IQ & Dunnett (2012). The use of rodent skilled reaching as a translational model for investigating brain damage and disease. Neurosci Biobehav Rev 36: 1030-1042.

Lelos MJ, Harrison DJ & Dunnett SB (2012). Intrastriatal excitotoxic lesion or dopamine depletion of the neostriatum differentially impairs response execution in extrapersonal space. Eur J Neurosci 36(10): 3420-3428.

Lindgren HS & Dunnett SB (2012). Cognitive dysfunction and depression in Parkinson’s disease – what can be learned from rodent models? Eur J Neurosci 35(12): 1894-1907.

Zietlow R, Precious SP, Kelly CM, Dunnett SB & Rosser AE (2012). Long-term expansion of human foetal progenitors leads to reduced graft viability in the neonatal brain. Exp Neurol 235(2): 563-573.

2011

Lane EL & Dunnett SB, eds (2011), Neuromethods: Animal Models of Movement Disorders Volume 1, Neuromethods series vol. 61, Humana Press / Springer, Totowa, USA, pp 1-447.

Lane EL & Dunnett SB, eds (2011), Neuromethods: Animal Models of Movement Disorders Volume 2, Neuromethods series vol. 62, Humana Press / Springer, Totowa, USA, pp 1-443.

Dunnett SB & Rosser AE (2011). Clinical translation of cell transplantation in the brain. Curr Opin Organ Transplant 16: 632-639.

Freeman TB, Cicchetti FC, Bachoud-Lévi AC & Dunnett SB (2011). Technical factors that influence neural transplant safety in Huntington’s disease. Exp Neurol, 227: 1-9.

Kelly CM, Precious S, Weyrauch U, Harrison A, Torres EM, Lane EL, Scherf C, Williams D, Baird AL, Penketh R, Kemp P, Amso NN, Dunnett SB & Rosser AE (2011). Medical abortion: a feasible alternative source of tissue for cell replacement therapy. Cell Transplant, 20: 503-513.

Klein A, Sacrey LAR, Dunnett SB, Whishaw IQ & Nikkhah G (2011). Proximal movements compensate for distal movement impairments in a real-world reach-to-eat task in Huntington's disease. Neurobiol Dis, 41: 560-569.

Lane EL, Daly CS, Smith GA & Dunnett SB (2011) Context-driven changes in l-DOPA-induced behaviours in the 6-OHDA lesioned rat. Neurobiol Dis 42: 99-107.

Lelos M, Harrison DJ & Dunnett SB (2011). Impaired sensitivity to Pavlovian stimulus-outcome learning after excitotoxic lesion of the ventrolateral striatum. Behav Brain Res. 225: 522-528.

Mazzocchi-Jones D, Döbrössy M & Dunnett SB (2011). Environmental enrichment facilitates long-term potentiation in embryonic striatal grafts Neurorehabil Neur Rep 25: 548-557.

Rosser AE, Kelly CN & Dunnett SB (2011). Cell transplantation for Huntington’s disease: practical and clinical considerations. Future Neurology. 6: 45-62.

Torres EM, Lane, EL, Heuer A, Smith GA, Murphy E & Dunnett SB (2011) Improvement of the rat 6-hydroxydopamine lesion of the median forebrain bundle by modification of the stereotaxic coordinates. J Neurosci Meth. 200: 29-35.

Trueman RC, Harrison DJ, Dunnett SB, Hoehn M & Farr T (2011). A critical re-examination of the intraluminal filament MCAO model: impact of external carotid artery transection. Translat Stroke Res 2(4): 651-661

2010

Iversen LL, Iversen SD, Dunnett SB & Björklund A, eds (2010), Dopamine Handbook, Oxford University Press, Oxford.

Döbrössy M, Busse M, Piroth T, Dunnett SB & Nikkhah G (2010). Neurorehabilitation with neural transplantation. Neurorehabil Neural Repair 24: 692-701.

Dunnett SB (2010). Neural transplantation Handbook of Clinical Neurology 95(55): 885-912.

 Lane EL & Dunnett SB (2010) Pretreatment with dopamine agonists influences L-dopa mediated rotations without affecting abnormal involuntary movements in the 6-OHDA lesioned rat. Behav Brain Res. 213(1): 66-72.

Twohig JP, Roberts MI, Gavalda N, Rees-Taylor EL, Adams D, Brooks SP, Bull MJ, Calder C, Cuff S, Yong AA, Alberch J, Davies A, Dunnett SB, Tolkovsky AM & Wang ECY (2010). Age-dependent maintenance of motor control and corticostriatal innervation by death receptor 3. J Neurosci 30: 3782-3792.

2009

Brooks SP & Dunnett SB (2009). Tests to assess motor phenotype in mice: a user’s guide. Nature Rev Neurosci 10(7): 519-528.

Kelly CM, Precious SV, Battersby A, Williams L, Scherf C, Penketh R, Amso N, Allen ND, Dunnett SB, Rosser AE (2009). Neonatal desensitisation allows long-term survival of neuronal xenotransplantation without chronic immunosuppression. Nature Methods 6(4): 271-273.

Trueman RC, Brooks SP, Jones L & Dunnett SB (2009). Rule learning, visuospatial function and motor performance in the HdhQ92 knock-in mouse model of Huntington’s disease. Behav Brain Res.clear203(2): 215-222.

Weyrauch UM, Torres EM, Baird AL & Dunnett SB (2009). A simple breeding protocol for procurement of accurately staged rat donor embryos for neural transplantation. Cell Transplant. 18(4):471-476.

2008

Cunha C, Angelucci A, D’Antoni A, Döbrössy M D, Dunnett SB, Berardi N & Brambilla R (2008). Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments. Neurobiol Dis. 33(3): 358-368.

Döbrössy MD & Dunnett SB (2008). Environmental housing and duration of exposure affect striatal graft morphology in a rodent model of Huntington’s disease. Cell Transplant. 17(10-11): 1125-1134.

Hodges AK, Hughes GP, Brooks SP, Holmans P, Dunnett SB & Jones L (2008). Brain gene expression predicts changes in behaviour in the R6/1 mouse model of Huntington’s disease. Genes Brain Behav 7(3): 288-299.

Mazzocchi-Jones D, Döbrössy MD & Dunnett SB (2009).Embryonic striatal grafts restore bi-directional synaptic plasticity in a rodent model of Huntington’s disease. Eur J Neurosci 30: 2134-2142.

Monville C, Torres EM, Pekarik, V, Lane, EL & Dunnett SB (2009) Genetic temporal and diurnal influences on L-dopa induced dyskinesia in the 6-OHDA model. Brain Res Bull 78(4-5): 248-253.

Torres EM, Dowd E & Dunnett SB (2008). Recovery of functional deficits following early donor age ventral mesencephalic grafts in a rat model of Parkinson’s disease. Neuroscience 154(2): 631-640.

Torres EM, Weyrauch UM, Sutcliffe R & Dunnett SB (2008). A rat embryo staging scale for the generation of donor tissue for neural transplantation. Cell Transplant 17(5): 535-542.

Workman VL, Dunnett SB, Kille P & Palmer DD (2008). On-chip alginate microencap­s­ulation of functional cells. Macromolecular Rapid Communications 28(2): 165-170.

Zietlow R, Lane EL, Rosser AE & Dunnett SB (2008). Human stem cells for CNS repair. Cell Tiss Res 331(1): 301-322.

2007

Björklund A & Dunnett SB (2007). Dopamine neuron systems in the brain: an update. Trends Neurosci 30(5): 194-202.

Brooks SP, Trueman R & Dunnett SB (2007). Striatal lesions in the mouse disrupt acquisition and retention, but not implicit learning, in the SILT procedural motor learning task. Brain Res 1185: 179-188.

Dunnett SB & Rosser AE (2007). Stem cell transplantation for Huntington's disease. Exp Neurol 203(2): 279-292.

Jay JR & Dunnett SB (2007). An operant serial implicit learning task (SILT) in rats: task acquisition, performance and the effects of striatal lesions. J Neurosci Meth 163(2): 235-244.

Kelly CM, Precious S, Penketh R, Amso N, Dunnett SB & Rosser AE (2007). Striatal graft projections are influenced by donor cell type and not the immunogenic background. Brain 130(5): 1317-1329.

Kuhn A, Goldstein DR, Hodges A, Strand AD, Sengstag T, Kooperberg C, Becanovic K, Pouladi M, Cha JHJ, Hannan AJ, Hayden M, Leavitt B, Dunnett SB, Ferrante RJ, Albin R, Shelbourne P, Delorenzi M, Augood SJ, Faull RLM, Olson JM, Bates GP, Jones AL, and Luthi-Carter R (2007). Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Hum Mol Gen 16(5): 1845-1861.

Torres EM, Monville C, Gates MA, Bagga V & Dunnett SB (2007). Improved survival of young donor age dopamine grafts in a rat model of Parkinson’s disease. Neuroscience 146(4): 1606-1617.

Trueman RC, Brooks SP, Jones L & Dunnett SB (2007). The operant serial implicit learning task reveals early-onset motor learning deficits in a knock-in mouse model of Huntington’s disease. Eur J Neurosci 25(2): 551-558.

Workman VL, Dunnett SB, Kille P & Palmer DD (2007). Microfluidic chip-based synthesis of alginate microspheres for encapsulation of immortalised human cells. Biomicrofluidics 1(1): 014105, 1-9.

2006

Döbrössy MD & Dunnett SB (2006). Morphological and cellular changes within embryonic striatal grafts associated with enriched environment and involuntary exercise. Eur J Neurosci 24(11): 3223-3233.

Döbrössy MD & Dunnett SB (2006). The effects of lateralised training on spontaneous forelimb preference, lesion deficits and graft mediated functional recovery after unilateral striatal lesions in rats. Exp Neurol 199(2): 373-383.

Dunnett SB & White A (2006). Striatal grafts alleviate bilateral striatal lesion deficits in operant delayed alternation in the rat. Exp Neurol 199(2): 479-489.

Farrington M, Wreghitt TG, Lever AML, Dunnett SB, Rosser AE & Barker RA (2006). Neural transplantation in Huntington’s disease: the NEST-UK donor tissue microbio­l­og­ical screening programme and review of the literature. Cell Transplant 15(4): 279-294.

Pittenger C, Fasano S, Mazzocchi-Jones D, Scanlin H, Dunnett S, Kandel ER & Brambilla R (2006). Impaired bidirectional synaptic plasticity and procedural memory formation in striatum-specific CREB-deficient mice. J Neurosci 26(10): 2808-2813.

Torres EM, Meldrum A, Kirik D & Dunnett SB (2006). An investigation of the problem of two-layered immunohistochemical staining in paraformaldehyde fixed sections. J Neurosci Meth 158(1): 64-74.

White A & Dunnett SB (2006). Fronto-striatal disconnection disrupts operant delayed alternation performance in the rat. NeuroReport 17(4): 434-441.