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Prof Victor Duance  -  PhD

Link to ScopusTM Database

Selected Publications

Gilbert SJ, Blain EJ, Al-Sabah A, Zhang Y, Duance VC, Mason DJ (2012) The protein kinase, PKR plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes. eCM Journal 23: 41-57

Blain EJ, Duance VC (2011) Chapter 1.3 Tissue Injury and repair – meniscus. Oxford Textbook of Sports Injuries. Editors – Hutson M, Speed C. pp 45–53

Sally Roberts, Jai Trivedi & Victor C Duance  (2011) Chapter 1.4 The Intervertebral Disc And The Spine.  Oxford Textbook of Sports Injuries. Editors – Hutson M, Speed C. pp 54–61

Siyuan Li, Xiaoli Jia, Victor C Duance and Emma J Blain (2011) The effects of cyclic tensile strain on the organisation and expression of cytoskeletal elements in bovine intervertebral disc cells: an in vitro study.  Eur Cell Mater. 21:508-522

Philippa Parsons, Sophie J Gilbert, Anne Vaughan-Thomas, David A. Sorrell, Rebecca Notman, Mark Bishop, Deborah J. Mason and Victor C. Duance (2011) Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage. JBC 286: 34986-97

Khan IM, Gonzalez LG, Francis L, Conlan RS, Gilbert SJ, Singhrao SK, Burdon D, Hollander AP, Duance VC, Archer CW (2011). Interleukin-1β enhances cartilage-to-cartilage integration. Eur Cell Mater 22:190-201

Thomas RS, Clarke AR, Duance VC, Blain EJ. (2011) Interplay of Wnt3A and mechanical load in cartilage chondrocyte homeostasis: an in vitro study. Arthritis Res Ther 13: R203

Blain EJ, Ali AY, Duance VC (2010) Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Phytother Res 24: 905-12

Singhrao SK, Müller CT, Gilbert SJ, Duance VC, Archer CW. (2009) An immunofluorescence method for postembedded tissue in the acrylic resin Technovit 9100 New using fluorescein isothiocyanate secondary detection.  Microsc Res Tech 2009 Jul; 72(7):501-6

Gilbert SJ, Singhrao SK, Khan IM, Gonzalez LG, Thomson BM, Burdon D, Duance VC, Archer CW. (2009). Enhanced tissue integration during cartilage repair in vitro can be achieved by inhibiting chondrocyte death at the wound edge. Tissue Eng Part A 2009 Jul;15:1739-49

Vaughan-Thomas A, Dudhia J, Bayliss M, Kadler K, Duance V (2008) Modification of the composition of articular cartilage collagen fibrils with increasing age Connect Tiss Res 49(5):374-82

Khan IM, Gilbert SJ, Singhrao SK, Duance VC, Archer CW. (2008) Cartilage integration: evaluation of the reasons for failure of integration during cartilage repair. A review Eur Cell Mater 16:26-39

Davies LC, Blain EJ, Caterson B Duance VC (2008) Chondroitin Sulphate Impedes the Migration of a Sub-population of Articular Cartilage Chondrocytes Osteoarthritis Cartilage 16: 855-864

Gilbert S, Blain E, Duance V, Mason D. (2008) Sphingomyelinase decreases type II collagen expression in articular chondrocytes via the ERK signaling pathway Arthritis & Rheum 58:209-220

Davies LC, Blain EJ*, Gilbert SJ, Caterson B, Duance VC. (2008) The potential of IGF-1 and TGFbeta1 for promoting "adult" articular cartilage repair: an in vitro study. Tissue Eng Part A 14(7): 251-61

Li S, Duance VC, Blain EJ (2008) Zonal variations in cytoskeletal element organization, mRNA and protein expression in the intervertebral disc J Anat 213(6): 725-32

Selected Previous Publications

Flood S, Parri R, Williams A, Duance V, Mason D (2007) Functional ionotropic glutamate receptors modulate IL-6 and MMP-2 expression in fibroblast-like synoviocytes Arthritis & Rheum 56:2523-34

Li S, Duance VC & Blain EJ. F-actin cytoskeletal organization in intervertebral disc health and disease Biochem Trans 35(4)683-685 2007

Gilbert SJ, Duance VC, Mason DJ (2006) PKR: a novel role in arthritic disease. Current Rheumatology Reviews 2(1), 9-21 (Invited review).

Gilbert SJ, Blain EJ, Jones P, Duance VC, Mason DJ (2006) Exogenous sphingomyelinase increases collagen and sulphated glycosaminoglycan production by primary articular chondrocytes: an in vitro study. Arthritis Res Ther 8(4), R89-R100.

Blain EJ, Gilbert SJ, Duance VC (2006). Disassembly of the vimentin cytoskeleton disrupts articular cartilage chondrocyte homeostasis. Matrix Biology 25(7) 398-408.

Duance VC & Roberts S. (2004) “The Intervertebral Disc” in “Soft Tissue Rheumatology” Eds B Hazelman, G Riley and C Speed. pp 54-79.

Gilbert SJ, Duance VC , Mason DJ (2004) Does protein kinase R mediate TNF- a - and ceramide-induced increases in expression and activation of matrix metalloproteinases in articular cartilage by a novel mechanism? Arthritis Res Ther 6(1), R46-R55.

Duance VC (2003) Get connected with connective tissues. The Biochemist 25(5) 7-10

Blain EJ Mason D & Duance V (2003) Effect of mechanical stimulation on MMP expression in chondrocytes. Biorheology 40:111-117

Gilbert SJ, Duance VC & Mason DJ (2002) TNF-a up-regulates PACT and increases phosphorylation of PKR and eIF2-a in articular chondrocytes. Biochem. Soc Trans. 30(6)886-889

Blain EJ, Mason DJ & Duance VC (2002) The effect of thymosin b4 on articular cartilage chondrocyte MMP expression. Biochem. Soc Trans 30(6)879-882

Young RD , Vaughan -Thomas A, Wardale RJ, Duance VC (2002) Type II collagen deposition in cruciate ligament precedes osteoarthritis in the knee. Osteoarthritis Cartilage 10(5):420-8

Blain EJ, Gilbert SJ, Wardale RJ, Capper SJ Mason DJ & Duance VC (2001) Up-regulation of matrix metalloproteinase expression and activation following cyclical compressive loading of articular cartilage in vitro. Arch. Biochem. Biophys. 396: 49-55

Vaughan-Thomas, A., Young, RD, Phillips, AC and Duance, VC (2001) Interaction of type XI collagen with heparin: role in chondrocyte-matrix interaction J.Biol.Chem 276(7)5303-5309

Eriksen TA, Wright DM, Purslow PP & Duance VC (2001) The role of calcium in the mechanical properties of fibrillin. Proteins 45:90-95

Young RD, Lawrence PA, Duance VC, Aigner T & Monaghan P (2000) Immunolocalisation of collagen types II and III in single fibrils of human articular cartilage. J Histo Cytochem.48, 423-432.

Vaughan-Thomas, A, Gilbert, SJ, & Duance, VC (2000) Elevated levels of proteolytic enzymes in the aging human vitreous. Invest. Ophthalmol & Vis. Sci. 41, 3299-3304.

Wotton SF, Dieppe PA & Duance VC (1999) Identification of immunoreactive collagenous components in synovial fluids from arthritis patients. Rheumatology 38, 338-345.

Wardale, RJ & Duance, VC (1996). Collagen Expression in Chicken Tibial Dyschondroplasia. J. Cell Sci. 109, 1119-1131.

Wardale, RJ & Duance, VC (1994). Characterisation of articular and growth plate cartilage in porcine osteochondrosis. J. Cell. Sci. 107, 47-59.

Wardale, RJ & Duance VC (1993). Quantitation and immunolocalisation of porcine articular and growth plate cartilage collagens. J. Cell Sci. 105, 975-984.

Wotton, SF, Jeacocke, RE, Maciewicz, RA, Wardale, RJ, Duance, VC (1991). The application of scanning confocal microscopy in cartilage research. Histochem. J. 23, 328-335.

Gadher, SJ, Eyre, DR, Duance, VC, Wotton, SF, Heck, L, Schmid, TM & Woolley, D (1988). Susceptibility of cartilage collagens Types II, IX, X and XI to human synovial collagenase and neutrophil elastase. Eur. J. Biochem. 175, 1-7.

Wotton, SF, Duance, VC & Fryer, PR (1988). Type IX collagen. A possible function in articular cartilage. FEBS. Letts. 234, 79-82.

Black, CM, Duance, VC, Sims, TJ, Light, ND (1983) An investigation of the biochemical and histological changes in the collagen of the kidney and skeletal muscle in systemic sclerosis. Collagen & Rel. Res. 3, 231-244.

Black, C.M, Duance, VC, Light, ND and Bailey, AJ (1982) Immunological and biochemical investigation into collagen changes in scleroderma. Annals of Rheumatic Diseases 41, 194.

Duance, VC, Black, CM, Bailey, AJ, Hughes, GRV & Dubowitz, V (1980) Polymyositis. An immunofluorescence study on the distribution of collagen types. Muscle and Nerve, 3, 482-490.

Duance, VC, Stephens, HR, Dunn, M, Bailey, AJ & Dubowitz, V (1980) A role for collagen in the pathogenesis of muscular dystrophy? Nature, 284, 470-472.

Shimokomaki, M, Duance, VC & Bailey, AJ (1980) Identification of a new disulphide- bonded collagen from cartilage. FEBS Lett., 121, 51-54.

Bailey, AJ, Shellswell, GB & Duance, VC (1979) Identification of collagen isotypes in differentiating myoblasts and developing chick muscle. Nature, 278, 67-69.

Duance, VC, Restall, DJ, Beard, HK, Bourne, FJ & Bailey, AJ (1977) The location of three collagen types in skeletal muscle. FEBS Lett., 79, 248-252.