Prof Alun Davies FRS
GFP-transfected embryonic sensory neuron in culture
We use a variety of approaches to investigate how secreted signalling molecules affect the generation and survival of neurons and influence the establishment and modification of their connections in the developing vertebrate nervous system. We have established well-characterised cell culture systems to ascertain the roles of these factors at defined stages in neuroblast and neuronal development and we transgenic technology to investigate the consequences of mutations in the genes encoding these factors, their receptors and other regulatory molecules. We have a particular current interest in the role of the tumor necrosis factor superfamily in regulating the growth of neural processes.
Research Team Members
bIII tubulin stained cortical neurons in culture
Wellcome Trust Senior Investigator Award, 2014-2019, £2,043,743 'TNF superfamily forward and reverse signalling in neural development'