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Prof Alan Clarke  -  PhD

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 Selected Publications

Holik, Aliaksei Z., Young, Madeleine, Krzystyniak, Joanna, Williams, Geraint Trefor, Metzger, Daniel, Shorning, Boris and Clarke, Alan Richard 2014. Brg1 loss attenuates aberrant Wnt-signalling and prevents Wnt-dependent tumourigenesis in the murine small intestine. PLoS Genetics 10 (7) , e1004453. 10.1371/journal.pgen.1004453 

Marsh Durban, Victoria, Jansen, Marnix, Davies, Emma Jane, Morsink, Folkert H., Offerhaus, G. Johan A. and Clarke, Alan Richard 2014. Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer. American Journal of Pathology 184 (1) , pp. 86-91. 10.1016/j.ajpath.2013.10.003 

Phesse, Toby J., Myant, K. B., Cole, A. M., Ridgway, R. A., Pearson, Helen Betty, Muncan, V., van den Brink, G. R., Vousden, K. H., Sears, R., Vassilev, L . T ., Clarke, Alan Richard and Sansom, O. J. 2014. Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo. Cell Death and Differentiation 10.1038/cdd.2014.15 

Davies, Emma Jane, Marsh Durban, Victoria, Meniel, Valerie, Williams, Geraint Trfor and Clarke, Alan Richard 2014. PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine. The Journal of Pathology 10.1002/path.4312 

Khurana, Rimpi, Verma, Vinod, Rawoof, Abdul, Tiwari, Shrish, Nair, Rekha A., Mahidhara, Ganesh, Idris, Mohammed M., Clarke, Alan Richard and Kumar, Lekha 2014. OncomiRdbB: a comprehensive database of microRNAs and their targets in breast cancer. BMC bioinformatics 15 (1) , p. 15. 10.1186/1471-2105-15-15 

Holik, Aliaksei, Krzystyniak, Joanna, Young, Madeleine, Richardson, Kirsty, Jarde, Thierry, Chambon, Pierre, Shorning, Boris and Clarke, Alan Richard 2013. Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner. Stem Cells 31 (11) , pp. 2457-2466. 10.1002/stem.1498 

Hammoudi, Abeer, Song, Fei, Reed, Karen Ruth, Jenkins, Rosalind E., Meniel, Valerie, Watson, Alastair J. M., Pritchard, D. Mark, Clarke, Alan Richard and Jenkins, John R. 2013. Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). Biochemical and Biophysical Research Communications 440 (3) , pp. 364-370. 10.1016/j.bbrc.2013.08.076 

Marsh Durban, Victoria, Davies, Emma Jane, Williams, Geraint Trefor and Clarke, Alan Richard 2013. PTEN loss and KRAS activation cooperate in murine biliary tract malignancies. The Journal of Pathology 230 (2) , pp. 165-173. 10.1002/path.4189 

Parry, Lee, Young, Madeleine, El Marjou, Fatima and Clarke, Alan Richard 2013. Evidence for a crucial role of Paneth Cells in mediating the intestinal response to injury. Stem Cells 31 (4) , pp. 776-785. 10.1002/stem.1326

Greenow KR, Clarke AR, Williams GT Jones R. (2013) Wnt-driven intestinal tumorigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency. Oncogene 33 pp 4089-4096

Meniel V, Song F, Phesse T, Young MA,  Poetz O, Jenkins JR, Parry L, Williams GT, Dunwoodie S, Watson A and Clarke AR. (2013) Cited1 deficiency suppresses gut tumorigenesis. PloS Genetics 10.1371/journal.pgen.1003638

Marsh V, Davies EJ, Williams GT, Clarke AR. (2013) PTEN loss and KRAS activation cooperate in murine biliary tract malignancies. J Pathol. 230(2):165-73

Jardé T, Evans RJ, McQuillan KL, Parry L, Feng GJ, Alvares B, Clarke AR, Dale TC. In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system. Oncogene. 2013 Feb 14;32(7):883-93.

Parry L, Young M, El Marjou F, Clarke AR. Evidence for a crucial role of paneth cells in mediating the intestinal response to injury. Stem Cells. 2012 Apr;31(4):776-85.

Feng GJ, Cotta W, Wei XQ, Poetz O, Evans R, Jardé T, Reed K, Meniel V, Williams GT, Clarke AR, Dale TC. Conditional Disruption of Axin1 Leads to Development of Liver Tumors in Mice. Gastroenterology. Gastroenterology. 2012 Dec;143(6):1650-9

Reed KR, Tunster SJ, Young M, Carrico A, John RM, Clarke AR. Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice. Gut.  2012 Oct;61(10):1435-82011 Dec 3.

Shorning BY, Jardé T, McCarthy A, Ashworth A, de Leng WW, Offerhaus GJ, Resta N, Dale T, Clarke AR. Intestinal renin-angiotensin system is stimulated after deletion of Lkb1. Gut.  2012 Feb;61(2):202-13

Shaw PH, Maughan TS, Clarke AR. Dual inhibition of epidermal growth factor and insulin-like 1 growth factor receptors reduce intestinal adenoma burden in the Apc(min/+) mouse. Br J Cancer.  2011 Aug 23;105(5):649-5710.

Matthews JR, Sansom OJ, Clarke AR. Absolute requirement for STAT3 function in small-intestine crypt stem cell survival. Cell Death Differ. Cell Death Differ. 2011 Dec;18(12):1934-43.

Shorning BY, Griffiths D, Clarke AR. Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder. PLoS One. 2011 Jan 19;6(1):e16209.

Cole AM, Ridgway RA, Derkits SE, Parry L, Barker N, Clevers H, Clarke AR, Sansom OJ. p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium EMBO Mol Med. 2010 Nov;2(11):472-86

Cole AM, Myant K, Reed KR, Athineos D, Ridgway RA, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ. Cyclin D2-CDK4/6 is required for efficient proliferation and tumorigenesis following Apc loss. Cancer Res.  2010 Oct 15;70(20):8149-58.

Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, Marsh V, Wilkins JA, Athineos D, Muncan V, Kemp R, Neufeld K, Clevers H, Brunton V, Winton DJ, Wang X, Sears RC, Clarke AR, Frame MC, Sansom OJ. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev  Cell. 2010 Aug 17;19(2):259-69.

Buchert M, Athineos D, Abud HE, Burke ZD, Faux MC, Samuel MS, Jarnicki AG, Winbanks CE, Newton IP, Meniel VS, Suzuki H, Stacker SA, Näthke IS, Tosh D, Huelsken J, Clarke AR, Heath JK, Sansom OJ, Ernst M. Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo. PLoS Genet. 2010 Jan 15;6(1):e1000816.

Hay T, Matthews JR, Pietzka L, Lau A, Cranston A, Nygren AO, Douglas-Jones A, Smith GC, Martin NM, O'Connor M, Clarke AR. Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. Cancer Res. 2009 May 1;69(9):3850-5. Epub 2009 Apr 21.

Burke ZD, Reed KR,  Phesse TJ, Sansom OJ, Clarke AR and Tosh D. Liver zonation occurs through a beta-catenin dependent, c-Myc independent mechanism. Gastroenterology. 2009 Jun;136(7):2316-2324.e1-3.

Greenow K, Clarke AR and Jones R. Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation. Oncogene. 2009  Mar 19;28(11):1443-53.

Shorning B, Zabkiewicz J, McCarthy A,  Pearson H,  Winton DJ, Sansom OJ,  Ashworth A and  Clarke AR. Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine. PloS One. 2009;4(1):e4264. Epub 2009 Jan 23.