Prof Vladimir Buchman - MD PhD
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Link to ScopusTM Database
Selected Publications
Synucleins – function and dysfunction
Anwar A, Peters O, Millership S, Ninkina N, Doig N, Connor-Robson N, Threlfell S, Kooner G, Deacon RM, Bannerman DM, Bolam JP, Chandra SS, Cragg SJ, Wade-Martins R and Buchman VL (2011) Functional alterations to the nigrostriatal system in mice lacking all three members of the synuclein family. Journal of Neuroscience, in press.
Nguyen JV, Soto I, Kim K-Y, Bushong EA, Oglesby E, Valiente-Soriano FJ,Yang Z, Davis CO, Bedont JL, Son JL, Wei JO, Buchman VL, Zack DJ,Vidal-Sanz M, Ellisman MH and Marsh-Armstrong N (2011) Myelination transition zone astrocytes are constitutively phagocytic and have synuclein dependent reactivity in glaucoma. Proceedings of the National Academy of Sciences of the USA 108:1176-1181.
Venda LL, Cragg SJ, Buchman VL and Wade-Martins R (2010) 'Alpha'-Synuclein and dopamine at the crossroads of Parkinson’s. Trends in Neurosciences 33: 559-568.
Greten-Harrison B, Polydoro M, Tomita MM, Diao L,Williams AM, Nie EH, Tian N, Castillo PE, Buchman VL and Chandra S (2010) 'Alpha'/'beta'/'gamma'-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction. Proceedings of the National Academy of Sciences of the USA 107:19573-19578.
Al-Wandi A, Ninkina N, Millership S, Williamson SJM, Jones PA and Buchman VL (2010) Absence of 'alpha'-synuclein affects dopamine metabolism and synaptic markers in the striatum of aging mice. Neurobiology of Aging 31:796–804.
Burré J, Sharma M, Tsetsenis T, Buchman V, Etherton M and Südhof TC (2010) 'Alpha'-synuclein promotes SNARE-complex assembly in vitro and in vivo. Science 329:1663-1667.
Oort PJ, Knotts TA, Grino M, Naour N, Bastard J-P, Clément, K, Ninkina N, Buchman VL, Permana P, Luo X, Pan G, Dunn TN and Adams SH (2008) 'Gamma'-synuclein is an adipocyte-neuron gene coordinately-expressed with leptin and increased in human obesity. Journal of Nutrition 135:841-848.
Papachroni KK, Ninkina N, Papapanagiotou A, Hadjigeorgiou GM, Xiromerisiou G, Papadimitriou A, Kalofoutis A and Buchman VL (2007) Autoantibodies to 'alpha'-synuclein in inherited Parkinson’s disease. Journal of Neurochemistry 101:749–756.
Robertson DC, Schmidt O, Ninkina N, Jones PA, Sharkey J and Buchman VL (2004) Developmental loss and resistance to MPTP toxicity of dopaminergic neurons in substantia nigra pars compacta of 'gamma'-synuclein, 'alpha'-synuclein and double 'alpha'/'gamma'-synuclein null mutant mice. Journal of Neurochemistry 89:1126-1136.
Ninkina N, Papachroni, Robertson DC, Schmidt O, Delaney L, O’Neil F, Court F, Rosenthal A,Fleetwood-Walker SM, Davies AM and Buchman VL (2003) Neurons expressing the highest levels of 'gamma'-synuclein are unaffected by targeted inactivation of the gene. Molecular and Cellular Biology 23:8233-8245.
Dimebon and neurodegeneration
Shelkovnikova TA, Ustyugov AA, Millership SJ, Peters O, Anichtchik O, Spillantini MG, Buchman VL, Bachurin SO and Ninkina NN (2011) Dimebon does not affect the phenotype of transgenic mice overexpressing truncated (1-120) human 'alpha'-synuclein in dopaminergic neurons. Neurodegenerative Diseases, in press.
Yamashita M, Nonaka T, Arai T, Kametani F, Buchman VL, Ninkina NN, Bachurin SO, Akiyama H, Goedert M and Hasegawa M (2009) Methylene blue and dimebon inhibit aggregation of TDP-43 in cellular models. FEBS Letters 583:2419-2424.
Biological function of an adaptor/scaffolding protein Ruk/CIN85
Havrylov S, Redowicz MJ and Buchman VL (2010) Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy. Traffic 11: 721-731.
Nikolaienko O, Skrypkina I, Tsyba L, Fedyshyn Y, Morderer D, Buchman V, de la Luna S, Drobot L and Rynditch A (2009) Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation. Cellular Signalling 21:753-759.
Havrylov S, Ichioka F, Powell K, Borthwick EB, Baranska J, Maki M and Buchman VL (2008) Adaptor protein Ruk/CIN85 is associated with a subset of COPI coated membranes of the Golgi complex. Traffic 9:798-812.
Borthwick EB, Korobko IV, Luke C, Drel VR, Fedyshyn YY, Ninkina N, Drobot LB and Buchman VL (2004) Multiple domains of Ruk/CIN85/SETA/CD2BP3 are involved in interaction with p85 'alpha'-regulatory subunit of PI 3-kinase. Journal of Molecular Biology 343:1135-1146.
Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M and Gout I (2002) Ruk is ubiquitinated but not degraded by the proteasome. European Journal of Biochemistry 269:3402-3408.
Buchman VL, Luke C, Borthwick EB and Ninkina N (2002) Organisation of the mouse Ruk locus and expression of isoforms in mouse tissues. Gene 295:13-17.
Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Matsuka GB, Davies AM, Waterfield M and Buchman VL (2000) Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein. EMBO Journal 19: 4015-4025.
Some other stories
Korobko IV, Kalinichenko SV, Korobko EV, Ninkina NN, Kiselev SL and Buchman VL (2010) Pro-survival activity of the MAK-V protein kinase in PC12 cells. Cell Cycle 9:4248-4249.
Ruzov AS, Mertsalov IB, Meehan R, Kiselev SL, Buchman VL and Korobko IV (2004) Cloning and developmental expression of MARK/Par-1/MELK-related protein kinase xMAK-V in Xenopus laevis. Development, Genes and Evolution 214:139-143.
Nabirochkina E, Simonova OB, Mertsalov IB, Kulikova DB, Ladigina NG, Korochkin LI and Buchman VL (2002) Expression pattern of dd4, a sole member of the d4 family of transcription factors in Drosophila melanogaster. Mechanisms of Development 114:119-123.
Ninkina NN, Mertsalov IB, Kulikova DA, Alimova-Kost MV, Simonova OB, Korochkin LI, Kiselev SL and Buchman VL (2001) Cerd4, third member of the d4 gene family: expression and organization of genomic locus. Mammalian Genome 12:862-866.
Mertsalov IB, Kulikova DA, Alimova-Kost MV, Ninkina NN, Korochkin LI and Buchman VL (2000) Structure and expression of two members of the d4 gene family in mouse. Mammalian Genome 11:72-74.