Biomedicine (BM) lies at the interface between basic and preclinical research and investigates the fundamental mechanisms of the normal and disease processes that influence life-long health, spanning from conception into old age, and from the single cell to the whole organism in its environment.
Key questions we are addressing are:
- association of developmental adversity with later life disease
- co-occurrence of common diseases
- increasing disease prevalence with ageing.
The Division has direct linkage with two URIs (ECSCRI (Lead) and NMHRI), hosts the Arthritis Research UK (ARUK) centre and Wales Gene Park Genome Editing Facility. It has a developing association with the new DRI Centre.
BM incorporates the classic disciplines of genetics, physiology, cell biology, biochemistry and anatomy, principally using mammalian models with considerable strength in genetic/environmental manipulations and cell culture systems.
Its strategy is to focus on three areas:
1. Developmental Origins of Disease
Exploring mechanisms underpinning fetal programming, and the co-occurrence of common diseases. Using genetic and intervention models to study the whole organism in the environment from conception into old age. Uniting reproductive biology, childhood disorders and chronic diseases to support Life Long Health.
2. Mechanisms of Health and Disease
Informing our understanding of the causes and consequences of a number of important medical conditions including orphan diseases, cardiovascular disease, asthma, lung and pancreatic diseases, arthritis, neurodegeneration and cancer with a significant focus on cancer stem cells (ECSCRI). Characterising and stratifying chronic disease. Focused use and engineering of mammalian systems, both in vivo and in vitro.
3. Disease intervention
Developing therapeutic strategies aimed at preventing and treating disease. Drug discovery, delivery and biomarkers platforms including antibody therapies with translational impact complimented by stem cell research
Fellowships and PhD applications
The Division welcomes approaches by potential fellowship applicants. We have a dedicated team to support applications from highly motivated individuals whose research maps onto the divisional research areas.
We also welcome funded PhD students to host their research and expand our strategic research.
The School of Biosciences has held a Silver Athena SWAN award since 2016 in recognition of our commitment to family-friendly and flexible working policies and we welcome enquiries from a diverse range of backgrounds to utilise and harness the fullest range of experiences.
|Name||Area of interest|
|Professor Rosalind John - Head of Division||How Epigenetic Marks direct Mammalian Development and drive Human Disease.|
|Dr Fernando Anjos-Afonso||Biology of Haematopoietic stem/progenitor cells and their niche|
|Dr Emma Blain||Connective tissue mechanobiology.|
|Professor Vladimir Buchman||Functional significance of synuclein proteins in the normal and degenerating nervous system.|
|Professor Bruce Caterson||Monoclonal antibody technologies to study onset of degenerative joint diseases.|
|Dr Richard Clarkson||Apoptosis in normal mammary tissues and in models of breast cancer.|
|Dr Joaquín de Navascués Melero||Stem cell decisions during intestinal homeostasis.|
|Professor Vic Duance||Structure and function of the minor collagens of cartilage, cell signalling pathways associated with mechanical and cytokine mediated cartilage degeneration.|
|Dr Julia Gerasimenko||Molecular mechanisms of pathological processes in exocrine pancreas.|
|Dr Oleg Gerasimenko||Investigation of cell death mechanisms.|
|Dr Sarah Hall||Design, development and evaluation of physiology-related teaching and learning activities; authentic learning opportunities in the undergraduate curriculum.|
|Dr Tim Higgins|
|Dr Catherine Hogan||Epithelial cell-cell communication and pancreatic cancer.|
|Professor Clare Hughes||Cartilage proteoglycan metabolism in osteoarthritis.|
|Dr Helen Jones||Signalling mechanisms involved in cancer biology.|
|Professor Paul Kemp||Induced pluripotent stem cells, neurodegenerative diseases, ion channels and oxygen sensing.|
|Dr Alvin Kwan|
|Professor Francis Lai||Cell signalling proteins that regulate intracellular calcium release.|
|Dr Branko Latinkic||Cell fate determination in Xenopus.|
|Dr Deborah Mason||Signalling mechanisms regulating bone and cartilage turnover, in osteoporosis, rheumatoid arthritis and osteoarthritis.|
|Dr Helen McCarthy||Biology of both the articular cartilage progenitor cell and a meniscus-specific progenitor cell in human and equine tissue and their potential role in tissue repair and osteoarthritis.|
|Dr Larissa Nelson|
|Dr Lee Parry||Understanding the interaction between diet, microbiota, immunity and cancer.|
|Dr Girish Patel - Affiliated Research Staff||Skin cancer stem cells.|
|MRC Professor Ole Petersen CBE FRS||Calcium signalling: physiology & pathophysiology.|
|Dr Toby Phesse||Cell signalling and stem cell function during homeostasis, regeneration and cancer in the gastrointestinal tract.|
|Dr Zoe Prytherch||Human in vitro lung models.|
|Dr Jim Ralphs||The synthesis, deposition and organisation of collagenous matrices in highly ordered connective tissues.|
|Professor Dipak Ramji (Postgraduate Divisional Tutor)||Inflammation, atherosclerosis and regulation of gene expression.|
|Professor Daniela Riccardi||Molecular mechanisms of nutrient sensing.|
|Dr Kirsty Richardson|
|Dr Neil Rodrigues||Haematopoietic stem/progenitor cell biology and its dysregulation in myelodysplasia and myeloid leukaemia.|
|Dr Hannah Shaw|
|Dr Paul Shaw||Clinician with basic-science translational research interests in lung and GI cancers.|
|Dr Florian Siebzehnrubl||Regulation of tumour progression and therapy resistance in brain cancer.|
|Professor Matt Smalley||The role of normal mammary stem and progenitor cells in the generation of breast cancer phenotypic heterogeneity and cancer stem cells.|
|Dr Shiby Stephens||Clinical anatomist with research interest inhuman musculoskeletal pathologies.|
|Professor Karl Swann||The physiology of eggs at fertilisation and embryos during early development.|