PhD projects

“Nanotechnology induced prolonged antimicrobial activity of antibiotic loaded bone cement formulations.”

Background

Bone cement is routinely used during orthopaedic surgeries to fix orthopaedic devices to bones; besides this main function, bone cement is also employed to deliver antimicrobial drugs in order to prevent infections.

This feature has been achieved through mixing the drug in the bone cement dough. Unfortunately, infections can develop at the surgical site even months after the initial operation while the antibiotic release from bone cement can offer protection for the first few days post surgery.

The rising number of patients undergoing procedures requiring bone cement will lead to a growing number of patients experiencing the potentially life-threatening consequences of infections unless new solutions are developed as the current approaches to this problem are not satisfactory.

The project

During this project a novel nanocomposite biomaterial with an encapsulated nanotechnology-based delivery system able to archive a controlled, prolonged release of antimicrobial agents will be developed.

The aim of the project is to synthesise a variety of nanomaterials and establish the optimal nanocarrier construct to provide sustained antibiotic release from novel bone cement formulations. Additionally, cytocompatibiliy material and rheological properties of the nanocomposite bone cements will be evaluated.

The ideal candidate holds a first class or high 2.1 degree (non-UK equivalent) in chemistry, material science or pharmacy/pharmaceutical technology. Basic knowledge of applied microbiology is desirable but not necessary.

If you are interested, send an email along with your CV to:

Polina Prokoopvich

Dr Prolina Prokopovich

Lecturer in Biomaterials

Email:
prokopovichp@cardiff.ac.uk
Telephone:
+44 (0)29 2087 5820

Start date

October 2016

Funding

This project is funded by Welsh Government, Life Sciences Research Network and Cardiff University. Funding is available to UK and EU candidates.