'To create a step- change in the treatment, diagnosis and rehabilitation of arthritis via interdisciplinary research investigating relationships between mechanical loading, joint function, pain and inflammation.'
- Define how human joint function changes with age, exercise, disease and physiotherapy.
- Quantify forces within normal and diseased human joints.
- Provide clinical tools to quantify changes in human joint function for diagnosis and treatment.
- Identify biomarkers signifying abnormal joint loading, joint degeneration and repair.
- Identify mechanically regulated therapeutic targets for arthritis and osteoporosis.
- Identify pain indicators that correspond to joint loading.
- Identify therapies that target pain, pathology and inflammation in arthritis.
- Model processes that cause cements to crack and prostheses to fail.
- Improve cements and coatings to resist failure, enhance osseointegration and reduce infection.
- Identify factors that influence recovery and dysfunction to inform rehabilitation.